EFFECT OF PROTEIN MALNUTRITION ON THE WEIGHT AND SERUM ALBUMIN OF ALBINO RATS
Abstract
Background: Protein Malnutrition is one of the major mortality factors in the children of Pakistan. Not only do the children sufferfrom infections (because of low resistance secondary to malnutrition), but they also lose weight significantly. The two spectra of
the diseases are Kwashiorkor and Marasmus. We conducted this study on laboratory' animals to assess the weight change and
correlated it with the extent of malnutrition by studying and estimating the serum albumin levels as well. Methods: 40 male albino
rats of 2 weeks' age were used for the experiment. They were divided into Control and Experimental groups containing equal
number of animals. The experimental group was subjected to protein malnutrition for 3 to 6 weeks. They were killed with the
paired control animals. The parameters of the two groups were compared for statistical analysis. Results: The results showed
significant change in the weights of the experimental animals right from the first week of malnutrition while the change in serum
albumin level became significant after prolonged malnutrition. Conclusion: Protein malnutrition is reflected from the decrease in
the serum albumin levels of the animals and their weights are also decreased significantly.
References
Davidson S.. Passmore R.. Brok .I F., Truswell A.S. Proteins
and Protein energy malnutrition. In: Human Nutrition and
Dietetics. 6th edition, Churchill Livingstone. Edinburgh.
; pp 55-72, 303-316.
Udani P.M. "Protein Energy Malnutrition (P.E.M), Brain and
various facets of child development". Indian Journal of
Pediatrics, 1992; 59 (2): 165-186 Khan M., Baker J. Protein
Energy Malnutrition. In: Nutrition in Primary Health Care for
the young child Health publication Ltd., the Medical centre,
Khyaban-e-Iqbal, Shalimar 7/2, Islamabad. 1979; pp. 45-
Khan M.. Baker J. Protein Energy Malnutrition. In: Nutrition
in Primary Health Care. National Nutrition Foundation, the
Medical centre, 47-College Road. Shalimar 7/2. Islamabad.
; pp. 72-80.
Rodwell S., Williams. Essentials of Nutrition and Diet
Therapy. 3rd edition. The C.V, Mosby Company, St. Louis,
Missouri. 1982; pp. 3-10,35-47 and 191.
Muaku S.M., Beauloye V., Thissen J.P.. Underwood L.E..
Fossion C.. Gerard G. Ketelslegers J.M. Long term effects of
gestational protein malnutrition on postnatal growth, Insulin
like growth factor (IGF)-I and IGF binding proteins in rat
progeny". Pediatr Res 1996 Apr; 39(4ptl ):649-55.
Ramos C.F., Teixeira C.V., Passos M.C., Pazos-Moura C.C..
Lisboa P.C., Curty F.H., de Moura E G. Low protein diet
changes thyroid function in lactatin rats". Proc Soc Exp Biol
Med 2000 Sep; 224(4):256-63.
Qureshi M l.. Draz U., Feroze, N.. Jafri S.A. Effects of protein
malnutrition on the thyroid follicular cell size of albino rats".
JAMC 1998:10(2):27-31
Jacob S.. Lawrence A.G. "Effects of Protein malnutrition on
the mouse submandibular gland" J. Anat, 1989; 165 169- 175.
Delverdier M . Cabanie P.. Roome N., Enjalbert F , Van
Haverbeke (}.: Quantitative Histology of Rat Thyroid
Influence of Histologic Technique on the Morphometric
Data". Analytical and Quantitative Cytology and Histology.
a; 13, (2): 110-114.
Orien L.T.. Patricia P K.. Danforth E; Horton E S.
"Characteristics of Thyroid Function in Experimental Protein
Malnutrition". J. Nutr. 1979; 109 1321-1332.
1 I Heard C.R.C.. Stewart R.J.C. Protein-calorie deficiency
and disorders of the endocrine glands. Hormones. 1971.2: 40-
Fleagle J.G.. Samonds K W., I legs ted D.M. "Physical growth
of cebus monkeys, cebus albifrons. during protein calorie
deficiency". Am. J. Clin.Nutr. 1975; 28: 246-253.
13 Escriva F., Kergoat M., bailbe D., Pascual-Leone A M..
Portha B. Increased Insulin action in the rat after protein
malnutrition early in life". Diabetologia 1991: Aug; 34(8): 5
-64.
Resnik O., Morgane P.J., Hasson R.. Miller M Overt and
hidden forms of chronic malnutrition in the raland their
relevance to man". Neurosci Biobehav rev 1982
Spring;6(l):55-75.
Tulp O.L., Horton E.S. Effect of prolonged experimental
protein malnutrition and of refeeding on growth, adipose tissue
development and body composition in rats". J Nutr 1981 Jul;
(7): 1145-56.
16 Onura C., Maharajan G,. Singh A., Etta K.M. "Thyroid
status in various degrees of protein-calorie malnutrition in
children". Clin. Endocrinol. Oxf. 1983; 18(1): 87-93.
Ashraf T.S., Abd EL, Hadi H., Alan D.R. "Endocrine and
Amino acid changes in Protein Energy Malnutrition (PEMJ"
Journal of Tropical Pediatrics 1991; 37:331-332
Alleyne G A.O, Hay R W Picou D.I . Stanfield J.P .
Whitehead. R.G. Protein Energy Malnutrition". Edward
Arnold Publishers Ltd. London. 1979; pp. 25-53.
Akingbemt B.T., Aire T.A. Haematological and serum
biochemical changes in the rat due to protein malnutrition and
gossypo;-abanol interactions". J Comp pathol 1994 Nov;
(4):413-26
Downloads
How to Cite
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.