PREVALENCE OF GUSTATORY AND OLFACTORY IMPAIRMENT IN DIFFERENT STAGES OF SARS-COV-2 INFECTED PATEINTS IN ISOLATION WARD

Authors

  • Mor Khan Shar Pakistan Institute of Medical Sciences Islamabad
  • Faheem Ahmed Pirwani PIMS Islamabad
  • Zahoor Ahmed Rana PIMS Islamabad
  • Hamza Hassan Mirza PIMS Islamabad
  • Ahsan Ullah Rush School of dentistry SZABMU Islamabad
  • Bashir Ahmed Jalbani Bibi Aseefa Dental College SMBBMU Larkana

DOI:

https://doi.org/10.55519/JAMC-02-9228

Keywords:

Anosmia, Ageusia, Hypogeusia, SARS-COV-2 patients

Abstract

Background: To evaluate the prevalence of gustatory and olfactory impairment and its correlation with the severity of SARS-Cov-2 infection as per WHO guidelines. Methods: A total of 241 patients of both gender having age from 15–80 years were included in the study. It was cross Sectional study conducted at SARS-COV-2 Isolation wards of Pakistan institute of medical science Islamabad from 15thSeptember 2020 to 15th January 2021. Convenient sampling technique was used to collect data. A proforma was designed for this purpose. Participants were divided into 3 groups on the basis of age. Group-1 (15–30 years), group-2 (31–50 years) and group 3 (51–80 years). Further the participants were graded into mild, moderate and severe stages of Sars-Cov-2 infection according to WHO guidelines. Statistical analysis was performed by using SPSS version 20. Results: In this study 66% were male and 34% population were the female. Regarding the age groups 72% population were from the group-3. Results of study shows 47% in mild stage, 45% in moderate stage and 8% severe stage. The results regarding the Gustatory and Olfactory impairment showed that 126 had gustatory impairment while 130 patients had olfactory impairment. Conclusion: We found strong relationship of olfactory and gustatory changes associated with SARS-COV-2 patients. It is premature to conclude that taste and smell changes are strongly linked to SARS-COV-2 diagnosis. Further multi center researches are required to find out possible pathophysiological mechanism

Author Biographies

Faheem Ahmed Pirwani, PIMS Islamabad

medical officer oral and maxillofacial surgery

Zahoor Ahmed Rana, PIMS Islamabad

 Dean of dentitry and HOD oral and maxillofacial surgery

Hamza Hassan Mirza, PIMS Islamabad

Post-graduate Rigistrar oral and maxillofacial surgery

Ahsan Ullah Rush, School of dentistry SZABMU Islamabad

Registrar  oral and maxillofacial surgery

Bashir Ahmed Jalbani, Bibi Aseefa Dental College SMBBMU Larkana

Assistant Professor oral and maxillofacial surgery

References

Moro E, Priori A, Beghi E, Helbok R, Campiglio L, Bassetti CL, et al. The International EAN Survey on Neurological Symptoms in Patients With COVID-19 Infection. Eur J Neurol 2020;27(9):1727–37.

WHO. Coronavirus disease (‎COVID-19)‎: situation report, 163. 2020.

Li Lq, Huang T, Wang Yq, Wang Zp, Liang Y, Huang Tb, et al. COVID‐19 patients' clinical characteristics, discharge rate, and fatality rate of meta‐analysis. J Med Virol 2020;92(6):577–83.

Yan CH, Faraji F, Prajapati DP, Boone CE, DeConde AS. Association of chemosensory dysfunction and Covid‐19 in patients presenting with influenza‐like symptoms. Int Fourm Allergy Rhinol 2020;10(7):806–13.

Vaira LA, Salzano G, Fois AG, Piombino P, De Riu G. Potential pathogenesis of ageusia and anosmia in COVID‐19 patients. Int Forum Allergy Rhinol 2020;10(9):1103–4.

Vaira LA, Deiana G, Fois AG, Pirina P, Madeddu G, De Vito A, et al. Objective evaluation of anosmia and ageusia in COVID‐19 patients: single‐center experience on 72 cases. Head Neck 2020;42(6):1252–8.

WHO. Clinical management of COVID-19: interim guidance, 27 May 2020. World Health Organization, 2020.

Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol 2020;277(8):2251–61.

Vaira LA, Hopkins C, Salzano G, Petrocelli M, Melis A, Cucurullo M, et al. Olfactory and gustatory function impairment in COVID‐19 patients: Italian objective multicenter‐study. Head Neck 2020;42(7):1560–9.

Hajikhani B, Calcagno T, Nasiri MJ, Jamshidi P, Dadashi M, Goudarzi M, et al. Olfactory and gustatory dysfunction in COVID‐19 patients: A meta‐analysis study. Physiol Rep 2020;8(18):e14578.

Guan WJ, Zhong NS. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020;382(18):1708–20.

Giacomelli A, Pezzati L, Conti F, Bernacchia D, Siano M, Oreni L, et al. Self-reported olfactory and taste disorders in patients with severe acute respiratory coronavirus 2 infection: a cross-sectional study. Clin Infect Dis 2020;71(15):889–90.

Gorzkowski V, Bevilacqua S, Charmillon A, Jankowski R, Gallet P, Rumeau C, et al. Evolution of olfactory disorders in COVID‐19 patients. Laryngoscope 2020;130(11):2667–73.

Lechien JR, Chiesa-Estomba CM, Hans S, Barillari MR, Jouffe L, Saussez S. Loss of smell and taste in 2013 European patients with mild to moderate COVID-19. Ann Intern Med 2020;173(8):672–5.

Fodoulian L, Tuberosa J, Rossier D, Landis B, Carleton A, Rodriguez I. SARS-CoV-2 receptor and entry genes are expressed by sustentacular cells in the human olfactory neuroepithelium. BioRxiv 2020.

Eliezer M, Hautefort C, Hamel AL, Verillaud B, Herman P, Houdart E, et al. Sudden and complete olfactory loss of function as a possible symptom of COVID-19. JAMA Otolaryngol Head Neck Surg 2020;146(7):674–5.

Tong JY, Wong A, Zhu D, Fastenberg JH, Tham T. The prevalence of olfactory and gustatory dysfunction in COVID-19 patients: a systematic review and meta-analysis. Otolaryngol Head Neck Surg 2020;163(1):3–11.

Moein ST, Hashemian SM, Mansourafshar B, Khorram‐Tousi A, Tabarsi P, Doty RL. Smell dysfunction: a biomarker for COVID‐19. Int Forum Allergy Rhinol 2020;10(8):944–50.

Bagheri SH, Asghari A, Farhadi M, Shamshiri AR, Kabir A, Kamrava SK, et al. Coincidence of COVID-19 epidemic and olfactory dysfunction outbreak in Iran. Med J Islam Repub Iran 2020;34:62.

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020;382(8):727–33.

WHO. Coronavirus disease (‎‎ COVID-19)‎‎: situation report, 166. 2020.

Karimi-Galougahi M, Raad N, Mikaniki N. Anosmia and the need for COVID-19 screening during the pandemic. Otolaryngol Head Neck Surg 2020;163(1):96–7.

Hummel T, Landis BN, Hüttenbrink KB. Smell and taste disorders. GMS Curr Top Otorhinolaryngol Head Neck Surg 2011;10:04.

Published

2022-03-03