AN EARLY PRESENTATION OF SUPRAGLOTTIC LARYNGEAL PARAGANGLIOMA: CASE REPORT AND REVIEW OF LITERATURE
Abstract
A thirty-year-old male presented with progressive hoarseness and dysphagia for solids. Fibre optic laryngoscopy showed a right supraglottic mass. Subsequent CT imaging showed the location and extent of the mass. Biopsy revealed a Paraganglioma with cytokeratin negative and chromogranin positive cells. The mass was subsequently removed without complications. Follow up also showed no complications. Hoarseness and dysphagia resolved following tumour excision.References
Ferlito A, Silver CE, Bradford CR, Rinaldo A. Neuroendocrine neoplasms of the larynx: an overview. Head Neck 2009;31(12):1634–46.
Williams MD. Paragangliomas of the Head and neck: an overview from diagnosis to genetics. Head Neck Pathol 2017;11(3):278–87.
Hunt JL, Ferlito A, Hellquist H, Rinaldo A, Skálová A, Slootweg PJ, Willems SM, et al. Differential diagnosis in neuroendocrine neoplasms of the larynx. Adv Anat Pathol 2017;24(3):161–8.
Chetty R, Pillay P, Jaichand V. Cytokeratin expression in adrenal phaeochromocytomas and extra-adrenal paragangliomas. J Clin Pathol 1998;51(6):477–8.
Gnepp DR. Small cell neuroendocrine carcinoma of the larynx. A Critical review of the literature. ORL J Othorhinolaryngol Relat Spec 1991;53(4):210–9.
Baugh RF, Wolf GT, Krause CJ, Beals TF, Forastiere A. Small cell carcinoma of the larynx: results of therapy. Laryngoscope 1986;96(11):1283–90.
El-Naggar AK, Chan JK, Takata T, Grandis JR, Slootweg PJ. The fourth edition of the head and neck World Health Organization blue book: editors' perspectives. Hum Pathol 2017;66:10–2.
Lewis JS Jr, Spence DC, Chiosea S, Barnes EL Jr, Brandwein-Gensler M, El-Mofty SK. Large cell neuroendocrine carcinoma of the larynx: definition of an entity. Head Neck Pathol 2010;4(3):198–207.
Hirsch MS, Faquin WC, Krane JF. Thyroid transcription factor-1, but not p53, is helpful in distinguishing moderately differentiated neuroendocrine carcinoma of the larynx from medullary carcinoma of the thyroid. Mod Pathol 2004;17(6):631–6.
Woodruff JM, Huvos AG, Erlandson RA, Shah JP, Gerold FP. Neuroendocrine carcinomas of the larynx. A study of two types, one of which mimics thyroid medullary carcinoma. Am J Surg Pathol 1985;9(11):771–90.
Rubin JS, Silver CE. Surgical approach to submucosal lesions of the supraglottic larynx: the supero-lateral thyrotomy. J Laryngol Otol 1992;106(5):416–9.
Naik SM, Shenoy AM, Chavan P, Patil A, Gupta S. Laryngeal paraganglioma: A rare clinical entity managed by supraselective embolization and lateral pharygotomy. Indian J Otolaryngol Head Neck Surg 2013;65(1):95–104.
Barnes L. Paraganglioma of the larynx. A critical review of the literature. ORL J Otorhinolaryngol Relat Spec 1991;53(4):220–34.
Del Gaudio JM, Muller S. Diagnosis and treatment of supraglottic laryngeal paraganglioma: report of a case. Head Neck 2004;26(1):94–8.
Myssiorek D, Rinaldo A, Barnes L, Ferlito A. Laryngeal paraganglioma: an updated critical review. Acta Otolaryngol 2004;124(9):995–9.
Ferlito A, Barnes L, Rinaldo A, Gnepp DR, Milroy CM. A review of neuroendocrine neoplasms of the larynx: update on diagnosis and treatment. J Laryngol Otol 1998;112(9):827–34.
Langerman A, Athavale SM, Rangarajan SV, Sinard RJ, Netterville JL. Natural history of cervical paragangliomas: outcomes of observation of 43 patients. Arch Otolaryngol Head Neck Surg 2012;138(4):341–5.
Tobin HA, Harris HH. Nonchromaffin paraganglioma of the larynx. Case report and review of the literature. Arch Otolaryngol 1972;96(2):154–7.
Published
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.
