REACTIVE PLASMACYTOSIS: A DIAGNOSTIC CONUNDRUM IN ACUTE MYELOID LEUKAEMIA
Abstract
Bone-marrow being a home to various kinds of normal hematopoietic cells, sometime becomes overcrowded by abnormal cell population in malignancies like in acute myeloid leukaemia. One such dilemma in diagnosis betides when two abnormal cell populations in bone-marrow occur at the same time. A prime example is when reactive plasmacytosis in bone-marrow eventuate in relation with acute myeloid leukaemia (AML). Due to scarce amount of such cases reported, it is imperative to understand the difference between reactive plasmacytosis which arises after induction of chemotherapy and the one which is diagnosed along with AML, during initial diagnosis due to other causes, like infections and IL-6 production by the leukemic blast population. To substantiate these erstwhile arguments, the brief case history of a 45 years old female patient diagnosed with acute myeloid leukaemia with coincident reactive plasmacytosis having no previous history of chemotherapy is presented along with review of past published literature.References
Akhtar Y, Ahmad SQ, Jamal S. Acute Myeloid Leukemia with Plasmacytosis. J Islam Int Med Coll 2016;11(4):189–91.
Gupta M, Malik S, Kalra R, Sharma N, Singh S, Gupta V, et al. Etiological Profile of Plasmacytosis on Bone Marrow Aspirates. Dicle Tıp Dergisi 2016;43(1):1–4.
Wulf GG, Jahns-Streubel G, Hemmerlein B, Bonnekessen K, Wörmann B, Hiddemann W. Plasmacytosis in acute myeloid leukemia: two cases of plasmacytosis and increased IL-6 production in the AML blast cells. Ann Hematol 1998;76(6):273–77.
Rangan A, Arora B, Rangan P, Dadu T. Florid plasmacytosis in a case of acute myeloid leukemia: A diagnostic dilemma. Indian J Med Peadiatr Oncol 2010;31(1):36–8.
Stickler GB, Pinkel D. Plasmacytosis of Bone marrow and Hypergammaglobulinemia in Acute Leukemia: A Case Report. Pediatrics 1958;22(4):659–64.
Rosner F, Grünwald H. Multiple myeloma terminating in acute leukemia: Report of 12 cases and review of the literature. Am J Med 1974;57(6):927–39.
Lu-qun W, Hao L, Xiang-xin L, Fang-lin L, Ling-ling W, Xue-liang C, et al. A case of simultaneous occurrence of acute myeloid leukemia and multiple myeloma. BMC Cancer 2015;15(1):724.
Luca DC, Almanaseer IY. Simultaneous presentation of multiple myeloma and acute monocytic leukemia. Arch Pathol Lab Med 2003;127(11):1506–8.
Murukutla S, Arora S, Bhatt VR, Kedia S, Popalzai M, Dhar M. Concurrent acute monoblastic leukemia and multiple myeloma in a 66-year-old chemotherapy-naive woman. World J Oncol 2014;5(2):68–71.
Gavarotti P, Boccadoro M, Redoglia V, Golzio F, Pileri A. Reactive plasmacytosis. Case report and review of the literature. Acta Haematol 1985;73(2):108–10.
Wei A, Juneja S. Bone marrow immunohistology of plasma cell neoplasms. J Clin Pathol 2003;56(6):406–11
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