INTRAPELVIC PRESSURE CHANGES IN UNILATERAL OBSTRUCTIVE NEPHROPATHY
Abstract
Background: Ureteric obstruction leads to increase in the Intrapelvic pressure and this ultimately affects the kidneyleading to structural and functional changes. It is not possible to study it in human beings. Numerous animal models
have been employed in the past. We studied these changes by using dog as the experimental model. Methods:
Intrapelvic pressure changes were studied in dogs. Right side ureters were exposed by a midline incision and were
cannulated with feeding tubes. Feeding tubes were connected to sphygmomanometer and any type of leakage was
excluded. The intrapelvic pressure was raised to 150 mmHg for 30 minutes. X-ray films were taken to reveal the
escape routes in the kidney. Results: It was observed that the intrapelvic pressure did not remain as such and a drop
of pressure by 10-12 mmHg was noted in 30 minutes. The kidney parenchyma was outlined with streaks of dye
extending from the pelvis into the renal tissue. This showed pyelovcnous, pyelolymphatic or pyelotublar pathways
which arc normally lying dormant.
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