EFFECT OF HYPOPROTEINEMIA ON TREATMENT OUTCOME IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA
Abstract
Background: Malnutrition is prevalent on large scale in hospitalized patients which increasesmorbidity and mortality, reduces the effectiveness of medical treatment in our hospitals andimpairs the quality of life significantly. Early diagnosis and treatment of malnutrition is gainingthe significance day by day. Methods: A prospective study was carried out to assess the effects ofhypoproteinemia malnutrition on the treatment outcome of children with acute lymphoblasticleukemia. One hundred and sixty three patients with Acute Lymphoblastic Leukemia (ALL) belowthe age of 14 years with L1 and L2 FAB morphology were included in this study. Treatmentprotocol used was FBM. Patients were classified according to Waterlow classifications ofmalnutrition (1976). Group-I, as Well-Nourished children (WNC) and Group-II as Mal-nourishedchildren (MNC). Percentages in both groups were found out with respect to total expired, Relapsesand completed treatment. Results: In Group-I (WNC) 50 (81.96%) completed treatment and alive,5 (8.19%) relapsed and 6 (9.8%) expired. In Group-II (MNC) 31(30.39%) completed treatmentand alive,8 (7.84%) relapsed and 63 (61.76%) expired. Overall, in WNC group-I 50(30.67%)completed treatment and alive, 5 (3.07%) relapsed and 6(3.68%) expired. In MNC group-II 31(19.02%) completed treatment and alive, 8 (4.91%) relapsed and 63 (38.65 %) expired.Conclusion: Hypoproteinemia affects treatment outcome in children with acute LymphoblasticLeukemia.Keywords: Malnutrition, Acute lymphoblastic leukemia, Children, Prognosis, Serum ProteinReferences
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