TREATMENT OF CONDYLOMA ACUMINA WITH PODOPHYLLOTOXIN VERSUS COMBINATION THERAPY
Abstract
Condyloma acuminata is growing problem due to its resistance to conventionaltreatment, increased recurrence rate and its relationship with carcinoma. We havedesigned this study to evaluate the efficacy, adverse effects and immunomadulatingeffects of podophyllotoxin as a treatment modality of condyloma acuminate ascompared to podophyllotoxin plus interferon alpha-1 cream. Podophyllotoxin asmonotherapy and its combine1 ion therapy with interferon alpha-1 cream producedcomplete response in 40% and 68% while recurrence in 48%> and 20% patientsrespectively. Topical podophyllotoxin produced pain and inflammation while after itscombination with interferon alpha-1 cream. The incidence of adverse effects remainedthe same. Lymphoblast transformation activity and natural Killer activity wereperformed for every patient before either of treatment modalities and after only in caseof combination thereby.KEY WORDS: Condyloma acuminate podophyllotoxin, interferon alpha-1Lymphoblast transformation activity, Natural Killer activity.References
Cobb MW. Human Papilloma virus infection J. Am. Acad.
Dermatol. 1990: 22:547-566
Malegczyk J. Majewski S. Jablonska S. et al. Abrogated NKCell lysis of human papilloma virus (HPV)-16-bearing
Keratinocytes in patients with precancerous and cancerous
HPV-induced anogenital lesions. Int. J. Cancer 1989;
:209-214.
Kerbs HB. Management of human Papilloma virus
associated genital lesions in men. Obstet & Gynaecol. 1989;
:312-316.
Schultz RE. Miller JW, Macdonald GR, et al. Clinical and
molecular evaluation of Acetowhite genital lesions in men.
J. Urol. 1990; 143: 920 -923.
Cauda R, Tyring SK, Grossi CE. et al. Patients with
condylom acuminatum exhibit decreased Interleukin-2 and
interferon gamma production and depressed natural killer
activity. J. Clin. Immunol. 1987; 07:304-311.
Amman AJ, Abrams D. Conant M. et al. Acquired
dysfunction in homosexual men, immunologic profile. Clin
Immun & Immunpath. 1983; 27:315-325.
Vesternen E. Meyer B, Cantell K, et al. Topical treatment of
flat vaginal condyloma with human leukocyte interferon.
Obstet. Gynaecol. 1984; 64:535-538.
Beutner KR, Conant MA, Friedman-Kien AE, et al. Patient
applied Podofilox for treatment of genital warts. Lancet
: 01: 831-834.
Von Krogh G. Penile condyloma acuminata: an
experimental model for evaluation of topical self-treatment
with 0.5-1% ethanoic preparations of Podophyllotoxin for
three days. Sex. Trans. Dis. 1981; 8:179-186.
Douglas JM Jr., Eron LJ, Judson FN, et al. A randomized
trial of combination therapy with intralesional interferon
alpha-2b and Podophyllin versus Podophyllin alone for the
therapy of anogenital warts. J. Infect. Dis. 1990; 162:52-59.
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.
