OCTREOTIDE IN THE MANAGEMENT OF ENTEROCUTANEOUS FISTULAE
Abstract
Efficacy of Octreotide (Somatostatin) in the conservative management ofpostoperative Enterocutaneous fistula was studied in seven patients with age
ranging 1 to 70 years. Four out of seven fistulae closed within 21 days of
starting the drug. One case, where fistula took over a month to close,
responded well in reducing the output significantly within 10 days of starting
therapy. The cases and the results are discussed. Favourable results following
Octreotide therapy in this study need strengthening by further studies.
References
Aguire A, et al. The role of surgery and hyper -
alimentation in therapy of gastrointestinal cutaneous
fistulae. Annals of Surg. 1194, 180: 393- 401.
Borison DI, et al. Treatment of Enterocutaneous and
Colocutaneous fistulae with early surgery and
Somatostatin analog. Dis. Col. Rec. 1992, 35: 635- 8.
Boike GM. Treatment of small intestinal fistula with
Octreotide, a Somatostatin analog. J. Surg. Oncol. 1992,
: 444-5.
Dicastanzo J et al. Somatostatin in persistent
gastrointestinal fistula treated by TPN. Lancet 1982, ii:
-339.
El-Bahar T & Irving M. Intestinal Fistulas. Recent
Advances in Surgery, 13, 1990; 103-124.
Hild P et al. Conservative treatment of fistulas of
pancreas and small intestine with Somatostatin. Ann.
Chir. 1982, 3: 193-196.
Harris GA. The role of Somatostatin and Somatostatin
analogs in the management of gastrointestinal disease.
Current Medical Literature, 1993: 40-42, London.
Irving M & Beadle C. External Intestinal Fistulas.
Clinics in Gastroenterology, 11: 327-336.
Kovacs HA, et al. Treatment of a chronic Gastro
cutaneous fistula with Octreotide in a pediatric patient.
; 15: A112 (Abs.685)
Nabiola-Calong P, et al. Blind evaluation of the efficacy
of Octreotide, a Somatostatin analog, on small bowel
fistula output. Lancet, 1987: 2: 672-3.
Nabiola P, et al. Treatment of 27 Enterocutaneous
fistulas with a half-life Somatostatin analog (SMS 201-
. Ann. Surg. 1989, 210: 56-58.
Ray-Jade C, et al. Octreotide in the management of postoperative Enterocutaneous fistulas and stress ulcer
bleeding. Am. J. Gastroenterol. 1992, 87: 1212-1215.
Sbanbhogue LKR, et al. Parenteral nutrition in the
surgical patient. Br. J. Surg. 1987, 74: 172-180.
Zera RT, et al. Enterocutaneous fistulas. Effect of TPN
and surgery. Dis. Col. Rec. 1983, 26: 109- 112.
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