GASTRIC ULCEROGENICITY OF FENOPRON ANTAGONIZED BY PARACETAMOL IN ALBINO RATS
Abstract
ABSTRACT:The ulcerogenic effect of fenopron and its protection by paracetamol was observed under
dissecting as well as laboratory microscope. The protection was complete under dissecting
microscope, in the dose of 250 mg/kg. body weight but there was significant decrease in erosion
score with gum acacia followed by Fenopron.
Mucosal thickness was significantly increased in paracetamol followed by fenopron group as
compared to other group. Increased secretory activity of mucous neck cells was observed in the
same group which might have resulted as protection of rat stomach by the damaging effect of
fenopron; due to increased production of mucous as well as prostaglandin.
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