MONOCLONAL GAMMOPATHY A THREE YEAR STUDY ON PARAPROEINEMIAS
Abstract
ABSTRACTSera from 22 patients (16 males + 6 females) with electrophoretically and immunologically
secured diagnosis of monoclonal gammopathy were tested for various biochemical parameters. The
final clinical diagnosis showing gamma-globulinemias in them was in the order of multiple
myeloma (MM) 20 nos, Waldenstrom macroglobulinemia (MW) 1 no. and light chain disease
(LCD) 1 no. The incidence of plasma cell neoplasm among Saudis is not very rare. The predominant
type is IgG myeloma (74%) with a kappa to lambda ratio of 2: 1. Bence Jones Proteinuria is
comparatively less common. Elevated levels of gamma glutamy l transpeptidase (GGT) in a good
number of patients indicate the high occurrence of hepatic involvement in such patients.
References
Kohn J.: A cellulose acetate supporting medium for zone electrophoresis. Clin. Chem. Acta. 1975,2, 297
Adams R.G, Smith L, Pickering P.E.C. The incidence of monoclonal proteins during seven years of screening in a
district general hospital. Immunology. 1984; 51: 451-454.
Whicher J. T: The interpretation of electrophoresis. Brit. J. Hosp. Med. 1980; 24: 348-360.
Whicher J.T.: Calvin J., J., Riches P., Warren C.: The laboratory investigation of paraproteinemia. Ann Clin. Biochem.
; 24: 119-132.
Pruzanski W: Clinical conditions associated with paraproteins. In Pruzanski W., Keystone E.C. (Eds): Paraproteins in
disease investigation of plasma cell dyscrasia. London: Churchill Livingstone, 1985; 15- 53 p. 15
Kyle R.A.: Multiple myeloma. Review of 869 cases. Mayo Clin. Proc. 50, 29, 1975.
Cohen C, Hamilton D.G.: Epidemiologic and histologic patterns of Hodgkin's disease. Comparison of black and white
populations of Johannesburg. Cancer. 46, 186, 1980.
Fine J.M., Lambin P, Leroux P.: Frequency of monoclonal gammopathy (M-components in 13400 sera from blood
donors. Vox. Sanguinis 23, 336, 1972.
Stirling G, Khalil A.M., Nada G.N. Malignant neoplasm in Saudi Arabia. Cancer. 44, 1543, 1979.
Under O.: Multiple myeloma. Dhahran health care experience. Annals of Saudi Medicine. 7,41,1987,
Berrebi A., Estrov Z: Twenty years follow up in a patient of multiple myeloma. Acta Haematological. 66, 269, 1981.
Parades J.M. Mitchell B.S., Multiple myeloma. Current concepts in diagnosis and management. Medical Clinics of
North America 64 (4), 1980.
Durie B.C.M., Salmon S.E.: clinical staging system for multiple myeloma with presenting clinical features, response to
treatment and survival. Cancer. 36, 842, 1975.
Hobbs J.R.: Growth and responses to treatment in human myelomatosis. Brit J. Haematol. 16, 607, 1969.
Perry M.C. Kyi R.A.: The clinical significance of Bence Jones proteinuria. Mayo Clin. Pro. 50, 234. 1975.
De Fronzo R.A., Cooke C.R. Wright J.R., Jumphery R.L.: Bence Jones proteinuria and renal failure in multiple
myeloma. Clin. Res. 22 468A, 1974.
Kohn J.: Cellulose acetate electrophoresis and immunoelectrophoresis. In: Smith I, ed. Chromatographic and
electrophoretic techniques. Vol. 2. London: Heinemann, 1976; p 90.
Whicher J.T., Warren C. Chambers R.E.: Immunochemical assays for immunoglobulin. Ann Clin. Biochem. 21,70,
Whicher J.T.: Immunofixation on cellulose acetate is more efficient than immunoelectrophoresis for detection of
paraproteins. Clin. Chem. 29, 402, 1983.
Bradly M., Schumann G.B., Ward P.C.J.: Examination of urine. In : Clinical diagnosis and management by laboratory
methods. In: Henry J.B.: (E.D) vol. 1. Philadelphia: Saunder W.B. 1979; p 559.
Tadashi K.: Delayed reaction of Bence Jones proteins to sulphosalicylic acid. Am. J. Clin Pathol. 86, 363, 1986.
Marinez M.M., Yuima J., Suki W.MN. Eknoyan G.: Renal complications in multiple myeloma. Physiology and some
aspects of clinical management. J. Chron. Dis. 24, 221, 1971.
Tubes R.R., Gephardt G.N. McMahan J.T., Hall P.M., Valenzuela R., Vidt D.G.: Light chain neuropathy. Am. J. Med
,263, 1981.
Pruzanski W., Gidon M.S., Roy A. Suppression of polyclonal immunoglobulin in multiple myeloma: Relationship to
the staging and other manifestations at diagnosis. Clinical Immunology and Immunopathology. 17, 280, 1980.
Zilvo J.E., Pennell P.R. (Eds): Clinical Chemistry in diagnosis and treatment. London: Lloyd-Luke Medical Books Ltd.
; p377.
Jeffery C., Eye M.K., Cohen H.J.: Evaluation of monoclonal gammopathies in the "well" elderly. Am. J. Med. 82, 39, 1987
Downloads
How to Cite
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.
