EFFECT OF ALLOXAN - INDUCED DIABETES ON SERUM ELECTROLYTES AND LIPIDS IN RABBITS

Authors

  • Muhammad Shafique
  • Misbahul Ain Khan
  • Amjad M. Chughtai
  • Akbar Ali Kahloon
  • Iqbal Ahmad Khan

Abstract

ABSTRACT:
Effect of alloxan on scrum glucose, electrolytes and lipids was observed in 20 induceddiabetic rabbits. Thirteen days after alloxan administration sufficient hyperglycemia was detected and
the serum levels of magnesium and sodium were lower significantly. Out of 20, eight Rabbits (40%)
developed marked hypomagnesemia and hyponatremia which were inversely associated with the
degree of hyperglycemia. Serum HDL-cholesterol was also decreased and triglycerides increased
statistically. However, the difference in the mean values of total cholesterol, calcium and potassium
were found to be non-significant after alloxan injection.

References

Marble A; White P; Bradely RF; Krall Lp. Joslin's Diabetes Mellitus, Eleventh ed, Lea and Febiger,

Philadelphia pp. 5-15, 1973.

Khilnani P. Electrolyte abnormalities in ill children. Critical care Medicine 20: 241, 1992.

Mather HM, Nisbet JA, Burton Gh. et al. Hypomagnesemia in diabetes. Clin, Chim. Acta, 95: 235,

Akhtar MS, Iqbal J. Evaluation of the hypoglycemic effect of achyranthes aspera in normal and alloxandiabetic rabbits. J. Ethnophannacology, 31; 49, 1991.5.

Lindermann RD; Adler S; Beard ES. Influence of various nutrients on urinary divalent cation excretion.

J. Lab. Clin. Med. 70: 236, 1967.

S Jorgen A: Hoven GH, Nilsson A. Magnesium. Zinc and potassium deficiency in Type I and Type II

diabetes, Acta Mdd. Scand, 224: 462, 1988.

McNair P; Madsbad S; Christensen MS. et al, Huypomagtiasemia, a risk factor in diabetic retinopathy,

Diabetes, 27: 1075, 1978.

Seeling MS; Heggtveit HA. Magnesium interrelationship in Ischemic heart disease. Amer J. Clin. Nutr.

: 59, 1974.

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How to Cite

Shafique, M., Khan, M. A., Chughtai, A. M., Kahloon, A. A., & Khan, I. A. (1992). EFFECT OF ALLOXAN - INDUCED DIABETES ON SERUM ELECTROLYTES AND LIPIDS IN RABBITS. Journal of Ayub Medical College Abbottabad, 5(2), 1–4. Retrieved from https://www.jamc.ayubmed.edu.pk/jamc/index.php/jamc/article/view/4724

Issue

Vol. 5 No. 2 (1992): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

REVIEW ARTICLE

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