COMPARISON OF PLASMA VISCOSITY AND FIBRINOGEN CONCENTRATION IN HYPERTENSIVE AND NORMOTENSIVE DIABETICS

Authors

  • Taj Muhammad Khan
  • Mumtaz Ali Marwat
  • Habibur Rehman

Abstract

Background: Body weight, body mass index, fibrinogen concentration and relative plasmaviscosity can contribute to the development of hypertension in diabetics. This study comparesbody weight, body mass index, fibrinogen concentration and relative plasma viscosity betweenhypertensive diabetics, normotensive diabetics and healthy controls. Methods: The present studywas carried out on normotensive and hypertensive diabetics taken from medical OPD of Saidugroup of teaching hospitals, Swat. A group of healthy male subjects between 30-60 years of agefrom the staff members of Saidu Medical College, Swat was also included. Each group comprisedof 35 subjects. Systolic and diastolic blood pressures, body weight, height, body mass index,fibrinogen concentration and relative plasma viscosity were measured and compared. Results:Body weight, body mass index, fibrinogen concentration and relative plasma viscosity were allsignificantly more in hypertensive diabetics than normotensive diabetics and healthy controlsubjects. Conclusion: The onset of the complications is different in the two groups of diabetics(hypertensive and normotensive), earlier in hypertensive diabetics and delayed in normotensivediabetics.Keywords: Plasma viscosity, Fibrinogen, Diabetes, Hypertension

References

Memeh CU, Reid HL. Plasma and serum viscosity in

Nigerian diabetics. Acta Diabetol Lat 1988;25:101-8.

McMillan DE. The microcirculation: Changes in diabetes

mellitus (Editorial). Mayo Clinic Proct 1988;63:517-20.

McMillan DE. Physical factors in the development of

atherosclerosis in diabetes. Diabetic Care 1981;30(2):97-104.

Anonymous: Diabetes and hypertension [editorial] Lancet

;ii:138-9.

Harkness J, Whittington RB. Blood plasma viscosity, an

approximate temprature invariant arising from generalized

concepts. Biorheology 1970;6:169-71.

Dormandy JA. Clinical importance of blood viscosity.

Viscostas 1979;I:5-8.

Zannad F, Voisin P, Brunnote F, Bruntz JF, Stoiz JF,

Gilgenkrantz JM. Haemoreological abnormalities in arterial

hypertension and their relation to cardiac hypertrophy. J

Hypertension 1988;6:293-7.

Reid HL, Obi GO, Oli JM. Reduced erythrocyte

deformability and hyperfibrinogenemia in Nigerian diabetics

with hemoglobin genotype HbAA. Acta Diabetol Lat

;21:105-14.

Oli JM, Iken VO. Diabetes mellitus and hypertension in an

African population. J R Coll Phys Lond 1986;20:32-5.

Memeh CU. Differences between plasma viscosity and

proteins of type-1 and type-2 diabetic Africans in early phase

of diabetes. Horm Metab Res 1990;25:21-3.

Phillips MJ. Plasma and whole blood viscosity . Br J

Hematol 1976;34:347-52.

Foster DW. Diabetes mellitus. In: Harrisons principles of

Internal Medicine. 14th ed. Newyork. McGraw-Hill Health

Professions Division, 1998; p 2060-81.

Steel RG, Torrie. Principles and Procedures of Statistics. 2nd

ed. NewYork, McGraw-Hill Book Co. Inc. 1980; p 90-3.

Reisin E, Abel R, Modan M, Silverbag DS, Eliahou HE,

Modan B. Effect of weight loss without salt restriction on

the reduction of blood pressure in overweight hypertensive

patients. N Engl J Med 1978;298:1-6.

Earnst E, Koenig W, Matrae A, Keel U. Plasma viscosity and

hemoglobin in the presence of cardiovascular risk

factors.Clin. Hemorheol 1988;8:507-15.

Sherma S. Platelet adhesiveness, Plasma fibrinogen in

juvenile-onset and maturity-onset diabetes mellitus. J Clin

Path 1981;34:501-3.

Klein Rbek, Klein SE, Moss MD, Davis DL, DeMets.

Glycosylated hemoglobin predicts the incidance and

progession of diabetes retinopathy. JAMA 1988;260:2864-

Chidi U, Memeh U. The relationship between body weight

and plasma viscosity in hypertensive diabetics. Nigerian J

Hypertension 1990;8:711-4.

Issue

Vol. 17 No. 4 (2005): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

License

Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License  CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.

USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.

AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.

Most read articles by the same author(s)