STUDY OF BLOOD LIPIDS, CORTISOL AND HAEMODYNAMIC VARIATIONS UNDER STRESS IN MALE ADULTS
Abstract
Background: Increased cholesterol in blood plays the role in atherosclerosis formation. It is observedthat stress increases cholesterol level. Most of previous studies were conducted on biological risk
factors like blood lipids under stress in middle aged persons who remained under investigations for
heart problems. Objective: The study was conducted to evaluate the changes in blood lipids and blood
cortisol along with sympatheo-adnergic responses determined by selected haemodynamic parameters
during psychological stress. Methods: Male participants (n=114) were randomly selected. They were
examined two times, for stress task of viva-voce (degree examination) and during non-stress period.
Final selection of participants was depending on stress assessment and their well being. Results:
Cortisol, systolic and diastolic blood pressures (SBP and DBP) and heart rate (HR) were significantly
increased during stress period with p<0.001 for each parameter. But different blood lipids levels (TC,
LDL-C, HDL-C and TG) were detected with different significant levels. The correlations of changed
lipids with raised findings of haemodynamics and cortisol were also evaluated. Conclusion: Further
studies in our population are needed to evaluate the relation of changes in various biological risk factors
including IL-9 and sympatho-adernergic activities with stress factors related to our social/
environmental problems, especially genetically based psychological factors.
Keywords: Cholesterols, Haemodynamics, Cortisol, psychological stress.
References
Ahaneku JE, Nwosu CM, Ahaneku GI, Farotimi. Lipid and
Lipoprotein Cardiovascular Risk Factor Responses to Episodic
Academic stress. J Health Sci 2001;47(3):323-6.
Knuepfer MM, Purcell RM, Gan Q, Le KM.. Hemodynamic
response patterns to acute behavioral stressors resemble those
to cocaine. Am J Physiol Regulatory Integrative Comp.
Physiol. 2001;281:R1778-86.
Marusic A, Gudjonsson GH, Eysenck HJ, Starc R. Biological
and psychosocial risk factors in ischaemic heart disease:
Empirical findings and a biopsychosocial model. Pers Individ
Dif. 1999;26:285-304.
Brunner EJ, Kivimaki M, Siegrist J, Luukkonen R, Riihimäki
H, Vahtera J, et al. Is the effect of work stress on
cardiovascular mortality confounded by socio-economic
factors in the Valmet study? J Epidemiol Community Health.
;58:1019-20.
Hemmingsson T, Lundberg I. Is the association between job
strain control and coronary heart diseases confounded by risk
factors measured in childhood and adolescence among
Swedish males 40 to 53 years of age? I Int J Epidemiol
;35:616-22.
Gregg ME, James JE, Matyas JA, Haemodynamic profile of
stress induced anticipation and recovery. Int Pscho-physiol,
;34(2):147-62.
Sternberg EM. Neuroendocrine regulation of autoimmune and
inflammatory disease. J Endocrinol 2000;169:429-35.
Andrew S, Lena B. Association between acute lipids stress
response at fasting levels 3 years later. Health Psychology
;24:601-7.
Muldoon MF, Herbert TB, Patterson SM, Kameneva M,
Raible R, Manuck SB. Effects of acute Psychological stress on
serum lipoid levels, hemoconcentration, and blood viscosity.
Arch Intern Med, 1995;155(6):615-20
Scheuch K, Pietruschka WD, Eckhardt G, Reinelt D, Richter
V, Reuter W. HDL and LDL cholesterol changes in
psychological stress in relation to stress experience. Z
Gesamte Inn Med, 1984;39(12):273-7.
McCann BS, Benjamin GA, Wilkinson. CW Retzlaff BM,
Russo J, Knopp RH. Plasma lipid concentrations during
episodic occupational stress. Ann Behav Med,
;21(2):103-10.
Kaasik AT, Jurimae T, Influence of four week examination
session stress and hypokinesia on serum lipoprotein pattern in
students. Can J Cardiol 1997;13:320.
Le Fur C, Romon M, Lebel P, Devos P, Lancry A, GuédonMoreau L, et al. Influence of mental stress and circadian cycle
on postprandial lipemia. Am J Clinical Nutrition.
,70:213-20.
Qureshi GM, Seehar GM, Ahmed Sangi SA, Pirzado ZA.
Blood cholesterol in Relation to Haemodynamic reactivity
under Examination stress. Professional Med J
;11(3):294-300.
Patterson SM, Gottdiener JS, Hecht G, Vargot S, Krantz DS..
Effects of acute mental stress on serum lipoids: mediating
effects of plasma volume. Psychosom Med 1993;55(6):525-32.
Calderon R Jr, Schneider RH, Alexander CN, Myers HF,
Nidich SI, Haney C. Stress, stress reduction and
hypercholesterolemia in Africa Americans: a review. Ethn
Dis, 1999;9(3):451-62.
Vogel JH, Bolling SF, Costello RB, Guarneri EM, Krucoff
MW, Longhurst JC, et al. Integrating complementary
medicine into cardiovascular medicine. A report of the
American College of Cardiology Foundation Task Force on
Clinical Expert Consensus Documents (Writing Committee to
Develop an Expert Consensus Document on Complementary
and Integrative Medicine).. Journal of American College of
Cardiology, 2005;46(1):184-221.
Alfredsson Alfredsson L, Hammar N, Fransson E, de Faire U,
Hallqvist J, Knutsson A, et al. Job strain and major risk factors
for coronary heart diseases among employed males and
females in a Swedish study on work, lipids and fibrinogen.
Scand J Work Environ Health, 2002;28:238-48.
Hücking K, Hamilton-Wessler M, Ellmerer M, Bergman RN.
Burst-like control of lipolysis by the sympathetic nervous
system in vivo. J Clin Invest 2003;11(2):257-64.
Gardner M, Gonzalez NA, Lao O, Calafill F, Bertranpetit J,
Comas D. Extreme population differences across Neuregulin-1
gene, with implication for studies. Mol Psychiatry
;11:66-75.
Mirka Hintsanen. Work stress and early atherosclerosis: Do
genetic back ground and pre-employment risk factors explain
conflicting findings? Thesis, University of Helsinki
Department of Psychology. 2006.
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