SCREENING OF 110 CIRRHOTIC PATIENTS FOR HEPATITIS B AND C AT SAIDU TEACHING HOSPITAL SAIDU SHARIF SWAT

Authors

  • Purdil Khan
  • Aziz Ahmad
  • Noor Muhammad
  • Taj Muhammad Khan
  • Bilal Ahmad

Abstract

Background: Cirrhosis liver is amongst the commonest clinical conditions in Pakistan. Besidesother causes, it is mostly related to previous viral infection, in this part of the world. The mainobjective of this study was to find the frequency of HBsAg and anti HCV in cirrhotic patients ofSwat district. Methods: This Prospective Study was conducted in the Medical unit of SaiduTeaching Hospital, Saidu Sharif from January 2006 to December 2006. One hundred and tenCirrhotic Patients, 62 Male and 48 Female aged from 14 to 75 years were included in this study.Sera were tested by 3rd generation Elisa method. Results: Fifty-nine out of 110 (53.6%) patientswere positive for anti HCV antibodies. Twenty-four (21.81%) Patients were positive for HBsAg.Eleven (10%) patients were positive for both HBsAg and anti HCV anti bodies. Sixteen (14.54%)were negative for both sero maker of hepatitis B and C. Conclusion: It is evident from this studythat Hepatitis C, is a leading cause of cirrhosis in District Swat followed by HBV. Both the virusesaccount for at least three fourths of the total Cirrhotic.Keywords: Cirrhosis liver, HBsAg, Anti HCV

References

Khan AA. Endemic transmission of Hepatitis C. J Coll

Physicians Surg Pak 1995;5:12–3.

Malik IA, Tariq W. The prevalence and pattern of viral

hepatitis in Pakistan (editorial). J Coll Physicians Surg Pak

;5:2–3.

Shamsuddin S. Portal systemic encephalopathy in chronic

liver disease: Experience of people Medical College, Nawab

Shah. J Coll Physicians Surg Pak 1998;8(2):53–5.

Ahmad SM, Malik IA, Tariq WUZ, Butt SA, Luqman M,

Ahmad N. Hepatitis B related chronic liver diseases in

Rawalpindi-Islamabad area. J Coll Physicians Surg Pak

;7(2):43–6.

Malik IA, Ahmad N, Butt SA, Tariq W, Muzaffar M, Bukhtiari

N, The role of hepatitis B & C virus in the aetiology of hepato

cellular carcinoma in northern Pakistan: a preliminary report.

J Coll Physicians Surg Pak 1995;5:26–8.

Anwaar AK, Khalil UR, Zulfiqar H and Farzana S Sero

Markers of hepatitis B and C in patients with cirrhosis. J Coll

Physicians Surg Pak 2002;12(2):105–7.

Maynard JE, khane MA, Hodersc. Global control of hepatitis

“B” through vaccine in the expended programme of

Immunization rev infect Dis 1989;11(Suppl):S574.

Javid IF, Rukhsana JF, Relative frequency of hepatitis ‘B’

virus and hepatitis ‘C’ virus infection in patients of cirrhosis

in NWFP. J Coll Physicians Surg Pak 2000;10(6):217–9.

Progress in the control of viral hepatitis memorandum from a

WHO meeting. Bull WHO 1988;66;443–55.

Abdul Baqi D, Asif B R, Hassan Sulman S and Bashirullah

M. The spectrum of chronic liver disease in Balochistan. J

Coll Physicians Surg Pak 2002;11(2):95–7.

Kuhul P, Seidal S, Stargel W, Beyer J, Sibrowski W, Flik J.

Antibody to hepatitis ‘C’ virus in German blood donors;

Lancet 1989;2(8658):234.

Saeed AA, Al Adwawi AA, Al Rashid H, Fairclough

D, Bacchus R, Ring C, et al. Hepatitis “C” virus infection in

Egyptian blood donors in Riyadh. Lancet 1991;338:459–60.

Ahmad A. Frequency of HBV surface Antigen and AntiHCV in Healthy Voluntary Blood donors in Swat district. J

Postgrad Med Inst 2006;20(2):187–90.

Khattak MF, Salamat N, Bhatti FA, Qureshi TZ.

Seroprevalence of Hepatitis B,C and HIV in blood donors in

North Pakistan. J Pak Med Assoc 2002:52:398–402.

Asif N, Khokar N, Illahi F. Seroprevalence of HBV, HCV

and HIV infection among voluntary non remunerated and

replacement donors in northern Pakistan. Pak J Med Sci

;20:24–8

Najmul Hassain S and Ghulam Shabir. A review of published

literature on hepatitis ‘B’ and ‘C’ virus prevalence in

Pakistan. J Coll Physicians Surg Pak 2002;12(6):368–71.

Qureshi H, Zuberi SJ, Lodi TZ, Alam E. Clinical features,

course, viral makers of follow-up in young versus adult non

J Ayub Med Coll Abbottabad 2009;21(1)

http://www.ayubmed.edu.pk/JAMC/PAST/21-1/Purdil.pdf 121

alcoholic cirrhotic: a retrospective study. Digestion

;42:110–5.

Umar M, Bushra HT, Younis N, Bashir N. Clinical spectrum

of chronic liver disease due to HCV, HBV and dual infection:

a comparative study. Pak J Gastroenterol 1999;13:1–3.

Lok AS, Ma CO, Hepatitis ‘B’ virus replication in Chinese

patients with HCC. Hepatol 1990;2:285–8.

Suerlock S, Foz RA, Niazi SP, Scheuer PJ. Chronic liver

disease and primary liver cell cancer with hepatitis associated

antigen in serum. Lancet 1970;1(7659):1243.

Shah SHA, Jafari SM, Hamid S, Ahmad A, Moid I, Nadeeur-Rahman. Spectrum of chronic liver disease at a University

Hospital in Karachi. Pakistan. Pakistan J Gastroenteral

;10:16–21.

Hussain I, Nasrullah M, Shah AA. Prevalence of hepatitis ‘B’

and ‘C’ infection in liver cirrhosis in Pakistan. Pak J

Gastroenterol 1997;11:7–11.

Malik A, Ahmed N, Luqmon Ml. Hepatitis “C” as a cause of

chronic liver disease in Northern Pakistan. J Pak Med Assoc

;42:67–8.

Mujeeb SA, Jamal Q, Khanani R, Iqbal N, Khar S.

Prevalence of HBsAg and anti HCV antibodies in hepatocellular carcinoma cases in Karachi. Pakistan. Trop Doct

;27:45–6.

Alter MJ, Margolis HS, Krawezynski K, Judson FN, Mares

A, Alexander WJ, et al. The natural history of community

acquired hepatitis ‘C’ in the United State. N Eng J Med

;327:1899–905.

Published

2009-03-01

Issue

Vol. 21 No. 1 (2009): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

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