EFFECT OF GLYCAEMIC STATUS ON LEFT VENTRICULAR DIASTOLIC FUNCTION IN NORMOTENSIVE TYPE 2 DIABETIC PATIENTS
Abstract
Background: Diabetes is associated with Left ventricular diastolic and systolic dysfunction known asdiabetic cardiomyopathy. Echocardiography is helpful for the detection of diastolic dysfunction andEchocardiographic screening for asymptomatic diabetic cardiomyopathy should be performed in allasymptomatic diabetic subjects. Identification of diabetic cardiomyopathy should result in the initiationof therapies to prevent the progression of diabetic cardiomyopathy. The objectives of this Descriptivecase series was to determine the effect of glycaemic status on left ventricular diastolic function innormotesive type 2 diabetic patients. Methods: This study was performed at Cardiology department,PGMI Lady Reading Hospital, Peshawar from March 2007 to September 2007. Sixty normotesive type2 diabetic patients were enrolled, 20 well control, 20 moderately control and 20 poorly control (Group-3). Main outcome measures was Left ventricular diastolic function determined by Echocardiography.Results: Out of 60 patients there were 32 (53.3%) males and 28 (46.7%) females. Mean E/A ratio inGroup 1 was 1.380.29, in Group 2 was 1.160.39 and in Group 3 was 0.600.15 (p<0.05). IVRT inGroup-1 was 917.87 mSec, in Group-2 was 1007.83 mSec and in Group-3 was 1096.45 mSec(p<0.05). DT in Group 1 was 207.2±12.6 mSec, in Group 2 was 21811.3 mSec and in Group 3 was229.7±9.52 mSec (p<0.05). Mean Em at mitral annulus in Group-1 was 0.14±0.04 m/Sec, in Group-2was 0.11±0.04 m/Sec and in Group-3 was 0.10±0.03 m/Sec (p=0.002). Left ventricular diastolicdysfunction was documented in 4 (25%) patients in Group-1, 9 (45%) patients in Group-2 and 16(80%) patients in Group-3 (p<0.05). There was Strong correlation between HbA1c level and diastolicindexes (p<0.05). Conclusion: Diastolic dysfunction is more frequent in poorly controlled diabeticpatients and its severity is correlated with glycaemic control.Keywords: Type 2 diabetes mellitus, left ventricular diastolic function, Deceleration timeReferences
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