AETIOLOGICAL CONSIDERATIONS OF ACQUIRED APLASTIC ANAEMIA
Abstract
Background: Acquired aplastic anaemia is one of the important causes of pancytopenia. This studywas conducted to observe the mode of presentation of acquired aplastic anaemia and to find out itspossible etiological factors. Methods: It is a hospital based descriptive study of 100 patients ofacquired aplastic anaemia. Results: Out of 100 patients 60 were male and 40 female. Majority (44%)of the patients were between 12–20 years of age. Patient presented with variable symptoms majority(40%) with fever. Most of the patients had haemoglobin levels between 4–6 gm/dl. (53%). Seventypercent of the cases had no obvious cause, while in 30% some known causative factors were found.Chloramphenicol was found to be the most common causative drug. Mortality was 35%. Thirtypatients were partially treated and 15 were lost to follow up. Twenty patients showed improvementwith treatment. Conclusions: Acquired aplastic anaemia is common among males and moreprevalent in younger age group. It is idiopathic in 70% cases while 30% had some cause. It has veryhigh mortality. Doctors need to keep in mind this fatal condition in patients presenting with anaemiaand should properly investigate before prescribing antibiotics and haematinics.Keywords: Aplstic anaemia pancytopenia, bone marrow suppressionReferences
Young NS, Maciejewski J. The pathophysiology of acquired
aplastic anaemia. N Eng J Med 1997;336:1365–72.
Aichison BP, Marsh JC, Hows JM, Russel NH, Gordon-Smith
EC. Pregnancy associated aplastic anaemia-report of five cases
and review of current management. Br J Haematol
;73:541–5.
Bakhshi S, Abella E. Aplastic anaemia. Available at:
http://emedicine.medscape.com/article/198759-overview.
Accessed on 7-6-2009.
Sleijfer S, Lugtenburg PJ. Aplastic anaemia: review. Neth J Med
;61(5):157–63.
Adil SN, Burney I A, Kakepoto G N, Khurshid M.
Epidemiological features of aplastic anaemia in Pakistan. J Pak
Med Assoc 2001;51:443–5.
Gordon Smith, E C and Issaragrisil, S Epidemiology of Aplastic
anaemia. Clin Haematol 1992;5:475–91.
Marsh JC, Ball Se, Darbyshire P, Gordon EC, Keidan AJ, Martin
A, et al. Guidelines for the diagnosis and management of
acquired aplastic anaemia. Br J Haematol 2003;123:782–801.
Young NS, Barrett AJ. The treatment of severe acquired aplastic
anaemia. Blood 1995;85:3367–77.
Naeem Khan M, Ayyub M, Nawaz KH, Naeem Naqi,
HussainT, Shujaat H, et al. Pancytopenia: Clinicopathological
study of 30 cases at Militiary Hospital Rawalpindi. Pak J
Pathol 2001;12:37–41.
Maluf EM, Pasquini R, Eluf JN, Kelly J, Kaufman DW. Aplastic
anaemia in Brazil- incidence and risk factors. Am J Haematol
;71:268–74.
Qazi RA, Masood A. Diagnostic evaluation of pancytopenia. J
Rawal Med Coll 2002;6:30–3.
Iqbal W, Hassan K, Ikram N, Nur S. Aetiological breakup in 208
cases of pancytopenia. J Rawal Med Coll 2001;5:7–10.
Kumar R, Kalra SP, Kumar H, Anand AC, Madan H.
Pancytopenia–a six-year study. J Assoc Physicians India
;49:1078–81.
Isenberg SJ. The fall and rise of chloramphenicol. JAAPOS
;7:307–8.
Fox LE, Ford S, Alleman AR, Homer BL, Harvey J. Aplastic
anaemia associated with prolonged high dose trimethoprimSulfadiazine administration in two dogs. Vet Clin Pathol
;22(3):89–92.
Muir KR, Chilvers Chief Executive,, Harriss C, Coulson L,
Grainge M, Darbyshire P, Geary C, Hows, J, Marsh J, Rutherford
T, Taylor M, Gordeon EC. The role of occupational and
environmental exposures in the aetiology of acquired severe
aplastic anaemia: a case control investigation. Br J Haematol
;123:904–14.
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