FREQUENCY OF OCULAR MANIFESTATIONS OF CHRONIC GRAFT VERSUS HOST DISEASE

Authors

  • Muhammad Aamir Arain
  • Muhammad Khizar Khizar Niazi
  • Muhammad Dawood Khan
  • Parvez Ahmed
  • Muhammad Afzal Naz
  • Muhammad Fayyaz

Abstract

Background: With the advancement of techniques for haematopoietic cell transplantation, the
number of transplant survivors is increasing rapidly and so are the chances of chronic graft versus
host disease (cGVHD). The ocular manifestations of this disease have not been explored in our
local population. This study was conducted to determine the frequency of ocular complications in
cases of cGVHD following successful bone marrow transplantation. Methods: Twelve diagnosed
cases of cGVHD were evaluated from June 2008 to March 2009 and there ocular manifestations
were noted especially the ocular surface disorders, using double staining method with fluorescein
and rose-bengal. Results: Nine patients (75%) were having dry eyes, 7 (58.3%) with mebomian
glands dysfunction, 4 (33%) with acute conjunctivitis, 2 (16.7%) with bilateral lacrimal
canalicular occlusion, and 1 (8.3%) each of bilateral posterior subcapsular cataract, unilateral
sterile corneal epithelial defect, anterior uveitis, retinal haemorrhages and disc oedema.
Conclusion: The higher frequency of dry eyes along with other ocular manifestations in patients
of cGVHD suggests the need of close ophthalmic monitoring in all such cases.
Keywords: Dry eyes, chronic graft versus host disease, haematopoietic cell transplantation

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Published

2010-03-01

How to Cite

Arain, M. A., Niazi, M. K. K., Khan, M. D., Ahmed, P., Naz, M. A., & Fayyaz, M. (2010). FREQUENCY OF OCULAR MANIFESTATIONS OF CHRONIC GRAFT VERSUS HOST DISEASE. Journal of Ayub Medical College Abbottabad, 22(1), 80–83. Retrieved from https://www.jamc.ayubmed.edu.pk/jamc/index.php/jamc/article/view/3091

Issue

Vol. 22 No. 1 (2010): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

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ORIGINAL ARTICLE

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