NOSOCOMIAL UROPATHOGENS AND THEIR ANTIBIOTIC SENSITIVITY PATTERNS IN A TERTIARY REFERRAL TEACHING HOSPITAL IN RAWALPINDI, PAKISTAN

Authors

  • Basharat Ali Khan
  • Sami Saeed
  • Adeel Akram
  • Faraz Basharat Khan
  • Amjad Nasim

Abstract

Background: Nosocomial urinary tract infections (NUTIs) are by definition not present atadmission of a patient and are acquired during hospitalisation. The objective of this study was tostudy the uropathogens and their antibiotic sensitivity patterns in hospital acquired urinary tractinfections presenting in a teaching hospital. Methodology: It was a retrospective descriptivestudy carried out at the Department of Pathology, Fauji Foundation Hospital, Rawalpindi,Pakistan, during the year 2009. Reports of urine culture and sensitivity performed during oneyear were retrospectively studied with a view to document various isolates and theirantimicrobial sensitivity. Results: Out of a total number of 1204 urine cultures submitted, 246were found to have nosocomial urinary tract infections. Over all prevalence of nosocomialurinary tract infection in the examined reports was 20.43%. Conclusion: Nosocomial Urinarytract infections are common. Gram negative bacilli are most frequent uropathogens and areresistant to commonly used antibiotics. Fosfomycin followed by Gentamycin and Cefotaximewere the most effective antibiotics.Keywords: uropathogens, antibiotics, urine, culture, sensitivity

References

Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM. CDC

definition for nosocomial infections. American journal of

infection control 1988;16:128–40.

Stamm WF. Catheter associated urinary tract infections:

Epidemiology, pathogenesis and prevention. Am J Med

;91(Suppl 3 B):655–715.

Warren JW. Catheter associated urinary tract infections. Infect

Dis Clin North Am 1997;11:609–22.

Davies HD, Jones EL, Sheng RY, Leslie B, Mathlow AG, Gold

R. Nosocomial urinary tract infection at a pediatric hospital. The

Pediatr Inf Dis J 1992;11:349–54.

Khan S, Ahmed A. Uropathogens and their susceptibility

patterns; A retrospective analysis. J Pak Med Assoc

;51(2):98–100.

Sharma S. Current understanding of pathogenic mechanisms in

UTIs. Ann Natl Acad Med Sci 1997;33(1):31–8.

Nelson DA, Differentiating prostate disorders. J Am Acad Nurs

Pract 1988;10:415–22.

Stark RP, Maki DG. Bacteriuria in a catheterized patient. N Eng J

Med 1984;311:560–4.

Gruneberg GN, Antibiotic sensitivities of urinary pathogens;

–1982. J Antimicrob Chemother 1984;14:17–23.

Farrell DJ, Morrissey I, De Rubies D, Robbins M, Felmingham

D. A UK Multicentre study of the antimicrobial susceptibility of

bacterial pathogens causing urinary tract infection. J Infect

;46(2):94–100.

Gupta V, Yadav A, Joshi RM. Antibiotic resistance pattern in

uropathogens. Indian J Med Microbiol 2002;20:96–8.

Kunin CM, Douthitt S, Dancing J, Anderson J, Moeschberger M.

the association between the use of urinary catheters and

morbidity and mortality among elderly patients in nursing home.

Am J Epidemiol 1992;135:291–301 .

Stark RP, Maki DG. Bacteriuria in catheterized patient. N Eng J

Med 1984;311:560–4 .

Ashkenzie S, Tov SE, Samra Z, Dinari G. uropathogens of

various childhood populations and their antibiotic susceptibility.

The Pediatr Inf Dis J 1991;10:742–6.

Grunberg RN. Changes in the antibiotic sensitivities of urinary

pathogens. 1971–1989. J Antimicrob Chemother 1990;26:3–11.

Published

2010-03-01

Issue

Vol. 22 No. 1 (2010): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

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