PREVALENCE OF HYPERTENSION AMONG OBESE AND NON-OBESE PATIENTS WITH CORONARY ARTERY DISEASE
Abstract
Background: Globally, obesity is now recognised as an epidemic. The degree of obesity isproportional to the rate of development of cardiovascular diseases, hence, resulting in a dramaticincrease in morbidity and mortality. Apart from obesity, hypertension is another well recognised riskfactor contributing to coronary artery disease (CAD). The precise prevalence of obesity-relatedhypertension varies with age, race and gender; and is yet unknown in our population. The objective ofthis study was to determine the prevalence of hypertension in obese and non-obese patients withdiagnosed CAD. Methods: This hospital based descriptive study was conducted in CardiologyDepartment of Postgraduate Medical Institute, Lady Reading Hospital, Peshawar from 15th March 2007to 30th May 2008. A total of 200 patients with diagnosed CAD were enrolled, 100 were found obeseand 100 non-obese. Results: Among these, a total of 111 (55.5%) were found to be hypertensive, 66(59.46%) of these were obese and 45 (40.54%) non-obese (p=0.003). Conclusion: Obese patients withCAD had significantly more frequent hypertension.Keywords: Coronary Artery Disease, CAD, Body Mass Index, BMI, Obesity, HypertensionReferences
Abbas S, Shazia A, Riaz A, Malik N. Risk factors for CAD
in Pakistan. Pak Armed Forces Med J 2003;53:12–9.
Samad A, Sahibzada WA, Mattu A. Risk factor analysis in
random population of 4 cities in Pakistan. Pak J Cardiol
;3:7–14.
Aziz-ur-Rahman, Sattar A, Abaidullah S, Hassan M.
Evaluation of cardiovascular risk factors in patient with
essential hypertension. Ann KE Med Coll 1999;5:134–-7.
Thomas F, Bean K, Pannier B, Oppert JM, Guize L, Benetos
A. Cardiovascular mortality in overweight subjects. The key
role of associated risk factors. Hypertension 2005;46:654–5.
Zahid A. Genetic aspects of human obesity. J Pak Med Assoc
;53:563–8.
World Health Organization. WHO world wide health report:
Reducing risks promoting healthy life. Geneva: World Health
Organization; 2002.
World Health Organization. WHO Reports 2004, WHO
global NCD infobase [Online] 2004 [Cited on August 13,
. URL: http//www.who.int/ncd_surveillance/infobase
Dawber TR. The Fragmington study: the epidemiology of
Atherosclerotic disease. Cambridge: Harvard University
press; 1980.p.257.
Dyer AR, Elliott P, Shipley M. Body mass index versus
height and weight in relation to blood pressure. Findings for
the 10,079 persons in the INTERSALT Study. Am J
Epidemiol 1990;131:589–96.
MacMahon SW, Blacket RB, Macdonald GJ, Hall W.
Obesity, alcohol consumption and blood pressure in
Australian men and women. The National Heart Foundation
of Australia Risk Factor Prevalence Study. J Hypertens
;2:85–91.
MacMahon S, Cutler J, Brittain E, Higgins M. Obesity and
hypertension: epidemiological and clinical issues. Eur Heart J
;8(Suppl B):57–70
Garrison RJ, Kannel WB, Stokes J 3rd, Castelli WP.
Incidence and precursors of hypertension in young adults: the
Framingham Offspring Study. Prev Med 1987;16:235–51.
Brown CD, Higgins M, Donato KA, Rohde FC, Garrison R,
Obarzanek E, et al. Body mass index and the prevalence of
hypertension and dyslipidemia. Obes Res 2000;8:605–19.
Joint National Committee on prevention detection evaluation
and treatment of high blood pressure. The sixth report of the
Joint National Committee on prevention, detection,
evaluation, and treatment of high blood pressure. Arch
Intern Med 1997;157:227–34.
Hanson L. Primary prevention of coronary heart disease:
what is left to be done? Medicographia 1998;20:183–6.
Ghaffar A, Reddy KS, Singhi M. Burden of noncommunicable diseases in South Asia. BMJ 2004;328:811–5.
Khan H, Hafizullah M, Ihtesham-ul-Haq. A hospital based
study on frequency of risk factors of coronary artery disease
in Peshawar. J Postgrad Med Inst 2005;19:270–5.
Hassan M, Awan ZA, Gul AM, Sahibzada WA, Hafizullah
M. Prevalence of coronary artery disease in rural areas of
Peshawar. J Postgrad Med Inst 2005;19:14–22.
Eisenstein EL, Shaw LK, Nelson CL, Anstrom KJ, Hakim Z,
Mark DB. Obesity and long-term clinical and economic
outcomes in coronary artery disease patients. Obes Res
;10:83–91.
Ruthan GH, Kuller LH. Morbidity associated with diastolic
hypertension and isolated systolic hypertension among men
screened for multiple risk factors intervention trial.
Circulation 1998;77:504–14.
J Ayub Med Coll Abbottabad 2010;22(2)
http://www.ayubmed.edu.pk/JAMC/PAST/22-2/Sher.pdf 133
Contaldo F, Pasanisi F, Finelli C, de Simone G. Obesity,
heart failure and sudden death. Nutr Metab Cardiovasc Dis
;12:190–7.
Lauer MS, Anderson KM, Levy D. Separate and joint
influences of obesity and mild hypertension on left
ventricular mass and geometry. J Am Coll Cardiol
;19:130–4.
Nishtar S. Prevention of coronary artery diseases in South
Asia. Lancet 2002;360:1015–8.
Bhopal R. Epidemic of cardiovascular disease in South
Asians. Prevention must start in childhood. BMJ
;324:625–6.
Sjostrom CD, Lissner L, Wedel H, Sjostrom L. Reduction in
incidence of diabetes, hypertension and lipid disturbances
after intentional weight loss induced by bariatric surgery: the
SOS Intervention Study. Obes Res 1999;7:477–84.
Downloads
Published
Issue
Section
License
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.