ASSESSMENT OF EFFICACY AND ADVERSE EFFECTS OF TRAZODONE IN THE TREATMENT OF MAJOR DEPRESSIVE DISORDER

Authors

  • Ali Gul Tunio
  • Moosa Khan
  • Dial Das
  • Ghulam Sarwar

Abstract

Background: Major depressive disorder is a serious and disabling illness in the world and iscommon chronic and recurrent disorder. It is the fourth most important cause of worldwide loss indisability. Methods: This was prospective and open-label study, study conducted in JPMC,Karachi, to evaluate the efficacy and adverse effects in major depressive disorder individuals. Atotal of 40 patients irrespective of the gender, aged 18 years up to 65 years were enrolled fromOPD of Psychiatry Department. Follow-up visits were carried out fortnightly after makingevaluation of symptoms at baseline visit (day 0), follow-up continued till 90 days when the resultswere compiled. Results: Statistically significant (p<0.05) results were observed in all theparameters at the end of study, i.e., day 90. Conclusion: Among all the symptoms of majordepressive disorder, trazodone proved to be more effective in controlling insomnia.Keywords: Trazodone, major depressive disorder, side effects, anxiolytics

References

Kasper S, Oliveri L, Di Loreto G, Dionisio P. A comparative,

randomized, double blind study of trazodone prolonged

release and paraoxetine in the treatment of patients with major

depressive disorder. Curr Med Res Opin 2005;21(8):1139–

Appelhof BC, Brouwer JP, van Dyck R, Fliers E, Hoogendijk

WJG, Yuyser J, et al. Triiodothyronine addition to paroxetine

in the treatment of major depressive disorder. J Clin

Endocrinol Metab 2004;89:6271–6.

Fava M, Kendler KS. Major depressive disorder. Neuron

;28:335–41.

Hsu GLK, Wan YM, Adler D, Rand W, Choi E, Tsang BYP.

Detection of major depressive disorder in Chinese Americans

in primary care. Hong Kong J Psychiatry 2005;15:71–6.

Newberg AB, Amsterdam JD, Wintering N, Ploessl K,

Swanson RL, Shults J et al. 123I-ADAM binding to serotonin

transporters in patients with major depression and healthy

controls. A preliminary study. J Nucl Med 2005;46:973–7.

Mann JJ. The medical management of depression. N Eng J

Med 2005;353:1819–34.

De Weid D, Sigling HO. Neuropeptides involved in the

pathophysiology of Schizophrenia and major depression.

Neurotoxicity Res 2002;4:453–68.

Robinson DS. Increased brain MAO-A levels in major

depressive disorder. Primary Psychiatry 2007;32–4.

Marazziti D, Consoli G, Golia F et al. Trazodone effects on

H]-paroxetine and α2-adrenoreceptors in platelets of

patients with major depression. Neuropsychiatric Dis

Arealment 2010;6:255–9.

Finkel R, Clark MA, Cubeddu LX, Harvey RA, Champe PC.

Nefazodone and Trazodone, antidepressant. In: Lippincott’s

Review Pharmacology, 4th Edition. 2009;p.141–58.

Sheehan DV, Croft HA, Gossen ER, Levitt RJ, Bulle C,

Bouchard S, et al. Extented release trazodone in major

depressive disorder. A randomized double blind, plecbo

controlled study. Psychiatry 2009;6(5):20–33.

Kaynak H, Kaynak D, Gözükirmizi E, Guilleminault C. The

effects of trazodone on sleep in patients treated with stimulant

antidepressants. Sleep Med. 2004;5(1):15–20.

de Meester A, Carbutti G, Gabriel L, Jacques JM. Fatal

overdose with trazodone: case report and literature review.

Acta Clin Belg 2001;56(4):258–61.c

Published

2010-09-01

Issue

Vol. 22 No. 3 (2010): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

License

Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License  CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.

USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.

AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.