AETIOLOGICAL PROFILE OF ACQUIRED ANAEMIA IN A PAEDIATRIC TERTIARY CARE SETTING
Abstract
Background: Anaemia is the commonest haematological disorder frequently faced by cliniciansworldwide. The multi-factorial aetiology of the disorder warrants a comprehensive search for the
different causes as management plans differ for different disorders. The objective of this study was to
identify the different acquired causes of anaemia in our paediatric population. Methods: The study
was conducted at the Department of Paediatrics, Ayub Teaching Hospital from April 2009 to April
2010. It was a cross-sectional study. A total of 110 patients were included in the study who presented
with anaemia secondary to acquired aetiologies and were assessed clinically using general physical
and systemic examination. The salient clinical and laboratory data was retrieved in designed protocol.
Results: Out of a total of 110 patients, 61 (55.5%) were male and 49 (44.5%) were female. Mean
age of the participants was 48 months. Nutritional anaemia comprising iron deficiency anaemia and
megaloblastic anaemia was the leading cause being present in 49 (44.5%) patients followed by
Visceral Leishmaniasis in 28 (25.5%) patients. Mean haemoglobin was 4.36 g/dl. Conclusion:
Anaemia secondary to acquired causes is a disorder with grave consequences ranging from cognitive
and psychomotor dysfunction to mortality in severe cases. Identification of the different acquired
causes is important in preventing the disorder by guiding appropriate interventions.
Keywords: Anaemia, nutritional, iron deficiency, megaloblastic, Visceral Leishmaniasis
References
Iron Deficiency Anaemia: Assessment, Prevention and Control:
A guide for programme Managers. Geneva: WHO 2001.
Desai MR, Terlouw DJ, Kwena AM, Phillips-Howard PA,
Kariuki SK, Wannemeuhler KA, et al. Factors associated with
hemoglobin concentrations in pre-school children in Western
Kenya: Cross-sectional studies. Am J Trop Med Hyg
;72(1):47-59.
DeMaeyer E, Adiels-Tegman M. The prevalence of anaemia in
the world. World Health Stat Quart 1985;38:302-16.
Hassan K, Sullivan MK, Yip R, Woodruff BA. Factors
Associated with Anaemia in Refugee Children. J Nut Metab
;127:2194-8.
Munot P, De Vile C, Hemingway C, Gunny R, Ganesan V.
Severe iron deficiency anaemia and ischaemic stroke in children.
Arch Dis Child 2011;96(3):276-9.
Mahmood A, Ahmed P, Altaf C, Aziz S, Azim W.
Clinicohaematological features of iron deficiency anaemia in
children between 1-5 years of age. Pak J Pathol 2006;17(3):101-4.
Mtvarelidze ZG, Kvezereli-Kopadze AN, Kvezereli-Kopadze
MA. Megaloblastic-vitamin B12 deficiency anaemia in childhood.
[Article in Russian]. Georgian Med News 2009;170:57-60.
Incecik F, Hergüner MO, Altunbaºak S, Leblebisatan G.
Neurologic findings of nutritional vitamin B12 deficiency in
children. Turk J Pediatr 2010;52(1):17-21.
Ranjan A, Sur D, Singh VP, Siddique NA, Manna B, Lal CS,
et al. Risk factors for Indian Kala-azar. Am J Trop Med Hyg
;73(1):74-8.
Malla N, Mahajan RC. Pathophysiology of visceral
leishmaniasis- some recent concepts. Indian J Med Res
;123:267-74.
Crawley J. Reducing the burden of anaemia in infants and young
children in malaria-endemic countries of Africa: From evidence
to action. Am J Trop Med Hyg 2004;71(2):25-34.
Menendez C, Fleming AF, Alonso PL. Malaria-related anaemia.
Parasitol Today 2000;16:469-76.
Teuffel O, Stanulla M, Cario G, Ludwig WD, Rottgers S,
Schafer BW, et al. Anaemia and survival in childhood acute
lymphoblastic leukemia. Haematologica 2008;93:1652-7.
Rana ZA, Rabbani MW, Sheikh MA, Khan AA. Outcome of
childhood acute lymphoblastic leukaemia after induction therapy-
years experience at a single paediatric oncology centre. J Ayub
Med Coll Abbottabad 2009;21(4):150-3.
Gaman A, Gaman G, Bold A. Acquired aplastic anaemia:
correlation between etiology, pathophysiology, bone marrow
histology and prognosis factors. Rom J Morphol Embryol
;50:669-74.
Matsumura I, Kanakura Y. Pathogenesis of anaemia of chronic
disease. Nippon Rinsho 2008;66:535-9.
J Ayub Med Coll Abbottabad 2011;23(4)
http://www.ayubmed.edu.pk/JAMC/23-4/Saima.pdf
Silverberg DS, Wexler D, Blum B, Iaina A. Anaemia in chronic
kidney disease and congestive heart failure. Blood Purif
;21(1):124-30.
Jain NB, Laden F, Guller U, Shankar A, Kazani S, Garshick E.
Relation between blood lead Organization levels and childhood
anaemia in India. Am J Epidemiol 2005;161:968-73.
de Benoist B, McLean E, Egli I, Cogswell M, (Eds). Worldwide
prevalence of anaemia 1993-2005: WHO global database on
anaemia. Geneva: WHO; 2008.
Javed S, Chaudhry R. Burden of anaemia and its determinants
among children under five years (6-59 months) of age in Tahsil
Kot Radha Kishen Distt Kasur Punjab. J Fatima Jinnah Med Coll
Lahore 2008;2(2):65-70.
Rehman HU, Fazil M, Khan FM. The etiology pattern of
Pancytopenia in children upto 15 years. Pak Armed Forces Med J
;53(2):183-7.
Memon S, Shaikh S, Nizamani AA. Etiological spectrum of
pancytopenia based on bone marrow examination in children. J
Coll Physicians Surg Pak 2008;18(3):163-7.
Manzoor A, Tayyib M, Tasneem T. Iron status of Anemic school
children. Pak Postgrad Med J 2003;14(1):14-7.
Hettiarachchi M, Liyanage C. Coexisting micronutrient
deficiencies among Sri Lankan pre-school children: a
community-based study. Matern Child Nutr 2012;8:259-66.
Di Martino L, Gramiccia M, Occorsio P, Di Muccio T, Scalone
A, Gradoni L. Infantile visceral leishmaniasis in the Campania
region, Italy: experience from a Paediatric Referral Centre.
[Article in Italian] Parassitologia 2004;46(1-2):221-3.
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