PROTECTIVE ROLE OF GINGER ON LEAD INDUCED DERANGEMENT IN PLASMA TESTOSTERONE AND LH LEVELS OF MALE SPRAGUE DAWLEY RATS
Abstract
Background: Lead is one of the most serious environmental threats to human health especially indeveloping countries. It damages multiple body systems including the reproductive system. Ginger’santioxidant and androgenic activity is reported in multiple animal studies. The aim of this study was toinvestigate the ameliorative effect of Zingiber officinale (ginger) on lead induced derangement inplasma testosterone and luteinizing hormone (LH) levels of male rats. Methods: Sixty adult maleSprague Dawley rats were used in this study in four groups. Group A served as normal control, GroupB received 0.3% lead acetate in drinking water, Group C and group D received supplementary 0.5 and1 gm/Kg bodyweight of ginger respectively along with lead acetate in drinking water. Five rats fromeach group were sacrificed at the end of 2nd, 4th and 6th weeks. Serum testosterone and LH levels wereanalysed using ELISA technique. Results: After co administration with different doses of ginger,serum testosterone level which was significantly decreased in lead treated group, showed a significantrise as compared to lead treated group. LH levels which had exhibited no significant change by leadtreatment, after co administration with different doses of ginger, again showed no significant change.Conclusion: Oral administration of ginger ameliorated lead induced testicular toxicity in male rats byincreasing serum testosterone level at all durations which might be a product of both its androgenic andantioxidant properties.Keywords: Lead toxicity, testosterone, luteinizing hormone, Zingiber officinale, male rats, antioxidantReferences
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