RELATIONSHIP BETWEEN ANAEMIA AND SIMPLE FEBRILE CONVULSIONS

Authors

  • Ambreen Sultan
  • Muhammad Fayaz
  • Abdul Najeeb Khan
  • Afnan Fayaz

Abstract

Background: Simple febrile seizures are the commonest convulsions occurring in children and its exact pathophysiology is unknown. Among other postulated reasons anaemia has been thought to be a possible aetiology. This study was conducted to find out any relationship between anaemia and simple febrile convulsions. Methods: We studied notes of 1,951 patients retrospectively who were admitted in the Women & Children Hospital Abbottabad from Jan 2013 to Aug 2013. Thirty-one patients with febrile seizures were included in the study as group I and another 31 patients matched for the demographic data were taken as group II. Degree of temperature, family history of simple febrile convulsions, underlying focus of infection and haemoglobin level were recorded. Results: Sixty-eight percent of patients in group I had Hb level below 11 gm/dl compared to 39% of patients in group II; 32% patients of group I, had level on/above 11 gm/dl but none of them had Hb above 11.5 gm/dl in comparison to group II where 61% had Hb level on/above 11 gm/dl with upper limit of 13 gm/dl. Conclusion: Significant association was found between anaemia and Simple Febrile Convulsions.Keywords: Simple Febrile Convulsions, Haemoglobin, iron deficiency, treatment, temperature

References

Shinnar S. Febrile seizures. In: Swaiman KF, Ashwal S, Ferriero DM, (Eds). Pediatric Neurology: Principles & Practice. 4th ed. Philadelphia: Mosby Elsevier; 2006. p. 1079–89.

Berg AT. The epidemiology of seizures and epilepsy in children. In: Shinnar S, Amir N, Branski D, (Eds). Childhood Seizures. Basel, Switzerland: S Karger; 1995.

Warden CR, Zibulewsky J, Mace S. Gold C, Gausche-Hill M. Evaluation and management of febrile seizures in the out-of-hospital and emergency department settings. Ann Emerg Med 2003:41:215–22.

Landreau-Mascaro A. Barret B, Mayauz MJ. Tradieu M. Blanches S. Risk of early febrile seizure with perinatal exposure to nucleoside analogues. Lancet 2002;259(9306):583–4.

Berg AT, Shinnar S, Shapiro ED, Salomon ME, Crain EF, Hauser WA. Risk factors for a first febrile seizure: a matched case-control study. Epilepsia 1995;36(4):334–41.

Pisacane A, Sansone R, Impaglizzo N, Coppola A, Ronaldo P, D’Apuzzo A, et al. Iron deficiency anaemia and febrile convulsions: case-control study in children under 2 years. BMJ 1996;313(7056):343.

Florentino RF, Guirric RM. Prevalence of nutritional anemia in infancy and childhood with emphasis on developing countries. In: Stekel A, (Ed). Iron nutrition in infancy and childhood. New York: Raven Press; 1984. p.61–74.

Stoltzfus R. Defining iron-deficiency anemia in public health terms: a time for reflection. J Nutr 2001:131(2S-2):565S–7S.

Kobrinsky NL, Yager JY, Cheang MS, Yatscoff RW, Tenebein M. Does iron deficiency raise the seizure threshold? J Child Neurol 1995;10(2):105–9.

World Health Organization. Iron Deficiency Anaemia Assessment, Prevention, and Control: A guide for programme managers. WHO; 2001. Available at: http://whqlibdoc.who.int/ hq/2001/WHO_NHD_01.3.pdf

Momen AA, Hakimzadeh M. Case control study of relationship between anemia and febrile convulsion in children between 9 months to 5 years of age. Jundishapur Sci Med J 2003;35(3):50–4. Available at: http://www.sid.ir/En/ViewPaperprint.asp?ID= 25918&varStr= [accessed March 15, 2013]

Bidabadi E, Mashouf M. Association between iron deficiency anemia and first febrile convulsion: A case-control study. Seizure 2009;18(5):347–51.

Lozoff B, Geogieff MK. Iron deficiency and brain development. Sermin Pediatr Neurol 2006;13(3):158–65.

Goldan Millichap J. Iron insufficiency as a risk factor for the febrile seizures. AAP Grand Rounds 2002;8(6):62–3.

Daoud AS, Batieha A, Faisel Abu-Ekteish, Ghaaibeh N, Ajlouni S, Hijazi S. Iron Status: A possible risk factor for foirst febrile seizure. Epilepsia 2002;43:740–3.

Naveed-ur-Rehman, Billoo AG. Association between iron deficiency anaemia and febrile seizures. J Coll Physicians Surg Pak 2005;15(6):338–40

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Published

2013-06-01