UNVEILING A RARE CASE OF KIKUCHI-FUJIMOTO IN SINDH, PAKISTAN

Authors

  • Saira Bano PNS Shifa, Karachi-Pakistan
  • Inshal Jawed Department of Internal Medicine, Dow University of Health Sciences, Karachi-Pakistan
  • Fasiha Bakhtawar Fatima Department of Internal Medicine, Dow University of Health Sciences, Karachi-Pakistan
  • Mohammad Omer Alam Sindh Medical College, Jinnah Sindh Medical University, Karachi-Pakistan
  • Ahsan Feroze Department of Internal Medicine, Jinnah Postgraduate Medical Center, Karachi-Pakistan

DOI:

https://doi.org/10.55519/JAMC-01-12794

Abstract

Kikuchi-Fujimoto disease (KFD) commonly manifests with symptoms of fever, tender cervical adenopathy, and systemic symptoms like night sweats, rashes, headache, weight loss, nausea, vomiting, and sore throat. In this case study, a 27-year-old patient's main complaints included fever, neck oedema, and weight loss that started one month ago. Following preliminary inquiries, ultrasonography, and CT scans, a multidisciplinary team has been overseeing the case. After a biopsy of axillary and cervical lymph nodes, it has been diagnosed as a case of Kikuchi-Fujimoto disease overlapping with Systemic Lupus Erythematous. Symptomatic and specific treatment started which showed improvement in 4 weeks. The treatment is symptomatic because of the benign characteristic and typical resolution within several weeks to months. The prognosis is usually excellent without an increased risk of malignancy or mortality.

Author Biographies

Saira Bano , PNS Shifa, Karachi-Pakistan

 

Inshal Jawed, Department of Internal Medicine, Dow University of Health Sciences, Karachi-Pakistan

 

Fasiha Bakhtawar Fatima , Department of Internal Medicine, Dow University of Health Sciences, Karachi-Pakistan

 

Mohammad Omer Alam , Sindh Medical College, Jinnah Sindh Medical University, Karachi-Pakistan

 

Ahsan Feroze , Department of Internal Medicine, Jinnah Postgraduate Medical Center, Karachi-Pakistan

 

References

Perry AM, Choi SM. Kikuchi-Fujimoto disease: A review. Arch Pathol Lab Med 2018;142(11):1341–6.

Hutchinson CB, Wang E. Kikuchi-fujimoto disease. Arch Pathol Lab Med 2010;134(2):289–93.

Bosch X, Guilabert A, Miquel R, Campo E. Enigmatic Kikuchi-Fujimoto disease: a comprehensive review. Am J Clin Pathol 2004;122(1):141–52.

Sarfraz S, Rafique H, Ali H, Hassan SZ. Case report: kikuchi-fujimoto disease: a case of supraclavicular lymphadenopathy. F1000Res 2019;8:1652.

Kuo TT. Kikuchi's disease (histiocytic necrotizing lymphadenitis). A clinicopathologic study of 79 cases with an analysis of histologic subtypes, immunohistology, and DNA ploidy. Am J Surg Pathol 1995;19(7):798–809.

Kato K, Ohshima K, Anzai K, Suzumiya J, Kikuchia M. Elevated serum-soluble Fas ligand in histiocytic necrotizing lymphadenitis. Int J Hematol 2001;73:84–6.

Kubota M, Tsukamoto R, Kurokawa K, Imai T, Furusho K. Elevated serum interferon γ and interleukin‐6 in patients with necrotizing lymphadenitis (Kikuchi's disease). Br J Haematol 1996;95(4):613–5.

Cuglievan B, Miranda RN. Kikuchi-Fujimoto disease. Blood 2017;129(7):917.

Joean O, Thiele T, Raap M, Schmidt RE, Stoll M. Take a second look: it’s Kikuchi’s disease! A case report and review of literature. Clin Pract 2018;8(4):1095.

Lelii M, Senatore L, Amodeo I, Pinzani R, Torretta S, Fiori S, et al. Kikuchi-Fujimoto disease in children: two case reports and a review of the literature. Ital J Pediatr 2018;44(1):83.

Feder Jr HM, Liu J, Rezuke WN. Kikuchi disease in Connecticut. J Pediatr 2014;164(1):196–200.e1.

Baenas DF, Diehl FA, Haye Salinas MJ, Riva V, Diller A, Lemos PA. Kikuchi–Fujimoto disease and systemic lupus erythematosus. Int Med Case Rep J 2016;29:163–7.

Downloads

Published

2024-04-17