THE DICHOTOMY BETWEEN HEAT SHOCK PROTEIN-27 AND MICROALBUMIN: COVARIATE OF EARLY DIABETIC NEPHROPATHY

Authors

  • Muhammad Irfan Department of Physiology, Bolan Medical College Quetta-Pakistan
  • Fatima Abid Department of Physiology, Jinnah Sindh Medical University, Karachi-Pakistan
  • Arfa Azhar Department of Biological and Biomedical Sciences, Aga khan University Hospital, Karachi-Pakistan
  • Mohammad Umair Farooqui Department of Pharmacy, Shaheed Mohtarma Benazir Bhutto Medical University, Larkana-Pakistan
  • Urooj Fatima Department of Anatomy, Jinnah Sindh Medical University, Karachi-Pakistan
  • Muhammad Subhan Siddiqui Jinnah Sindh Medical University, Karachi-Pakistan

Keywords:

Diabetes mellitus, Microalbumin, Diabetic Nephropathy

Abstract

Background: Heat shock protein-27 is the microprotein released from renal parenchyma during diabetic oxidative stress, while microalbumin is the plasma protein that appears in urine in diabetic nephropathy. Methods: This case-control study was conducted from Jan to Sep 2021 in the Physiology department, BMC, BMCH, Quetta. The current study included 105 patients with an age range from 30–50 years and was divided into three groups: i) a control group of healthy participants, ii) a diabetic risk group: participants without signs of diabetic nephropathy and diabetic duration from 1–5 years, iii) diabetic nephropathy group: participants having >30 mg/dl of v microalbumin in urine and diabetic duration from 5–10 years. Results: There were significant mean differences between all groups with respect to anthropometric measurements except in height amongst all groups. Statistically significant mean differences were seen in the risk and nephropathy group with respect to serum FBG, RBG, and HbA1c. Elevated microalbumin levels in the diabetic nephropathy group (50.9±8.2) compared with the diabetic risk group (15.4±2.9). Similarly, higher levels of HSP-27 were seen in the diabetic nephropathy group (230.46±23.75) as compared with the diabetic risk group (117.60±14.50). Conclusion: HSP-27 is a better biomarker than microalbumin and may show early glomerular injury in the early diabetic stage of diabetic nephropathy

Author Biographies

Muhammad Irfan, Department of Physiology, Bolan Medical College Quetta-Pakistan

 

Fatima Abid, Department of Physiology, Jinnah Sindh Medical University, Karachi-Pakistan

 

Arfa Azhar, Department of Biological and Biomedical Sciences, Aga khan University Hospital, Karachi-Pakistan

 

Mohammad Umair Farooqui, Department of Pharmacy, Shaheed Mohtarma Benazir Bhutto Medical University, Larkana-Pakistan

 

Urooj Fatima, Department of Anatomy, Jinnah Sindh Medical University, Karachi-Pakistan

 

Muhammad Subhan Siddiqui, Jinnah Sindh Medical University, Karachi-Pakistan

 

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Published

2024-02-05

Issue

Vol. 36 No. 1 (2024): JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD

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ORIGINAL ARTICLE

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Copyright (c) 2024 Muhammad Irfan, Fatima Abid, Arfa Azhar, Mohammad Umair Farooqui, Urooj Fatima, Muhammad Subhan Siddiqui

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