THE DICHOTOMY BETWEEN HEAT SHOCK PROTEIN-27 AND MICROALBUMIN: COVARIATE OF EARLY DIABETIC NEPHROPATHY
DOI:
https://doi.org/10.55519/JAMC-01-12499Keywords:
Diabetes mellitus, Microalbumin, Diabetic NephropathyAbstract
Background: Heat shock protein-27 is the microprotein released from renal parenchyma during diabetic oxidative stress, while microalbumin is the plasma protein that appears in urine in diabetic nephropathy. Methods: This case-control study was conducted from Jan to Sep 2021 in the Physiology department, BMC, BMCH, Quetta. The current study included 105 patients with an age range from 30–50 years and was divided into three groups: i) a control group of healthy participants, ii) a diabetic risk group: participants without signs of diabetic nephropathy and diabetic duration from 1–5 years, iii) diabetic nephropathy group: participants having >30 mg/dl of v microalbumin in urine and diabetic duration from 5–10 years. Results: There were significant mean differences between all groups with respect to anthropometric measurements except in height amongst all groups. Statistically significant mean differences were seen in the risk and nephropathy group with respect to serum FBG, RBG, and HbA1c. Elevated microalbumin levels in the diabetic nephropathy group (50.9±8.2) compared with the diabetic risk group (15.4±2.9). Similarly, higher levels of HSP-27 were seen in the diabetic nephropathy group (230.46±23.75) as compared with the diabetic risk group (117.60±14.50). Conclusion: HSP-27 is a better biomarker than microalbumin and may show early glomerular injury in the early diabetic stage of diabetic nephropathyReferences
WHO. Global status report on alcohol and health 2018: World Health Organization; 2019.
Chen WZ, Hung CC, Wen YW, Ning HC, Gau BR, Huang YY. Effect of glycemic control on microalbuminuria development among type 2 diabetes with high-normal albuminuria. Renal Fail 2014;36(2):171–5.
Choi SK, Kam H, Kim KY, Park SI, Lee YS. Targeting Heat Shock Protein 27 in Cancer: A Druggable Target for Cancer Treatment? Cancers (Basel) 2019;11(8):1195.
Bellini S, Barutta F, Mastrocola R, Imperatore L, Bruno G, Gruden G. Heat Shock Proteins in Vascular Diabetic Complications: Review and Future Perspective. Int J Mol Sci 2017;18(12):2709.
Saleem T, Dahpy M, Ezzat G, Abdelrahman G, Abdel-Aziz E, Farghaly R. The Profile of Plasma Free Amino Acids in Type 2 Diabetes Mellitus with Insulin Resistance: Association with Microalbuminuria and Macroalbuminuria. Appl Biochem Biotechnol 2019;188(3):854–67.
Merlot AM, Kalinowski DS, Richardson DR. Unraveling the mysteries of serum albumin-more than just a serum protein. Front Physiol 2014;5:299.
Thethi TK, Batuman V. Challenging the conventional wisdom on diabetic nephropathy: Is microalbuminuria the earliest event? J Diabetes Complications 2019;33(3):191–2.
Muddu M, Mutebi E, Ssinabulya I, Kizito S, Mulindwa F, Kiiza CM. Utility of albumin to creatinine ratio in screening for microalbuminuria among newly diagnosed diabetic patients in Uganda: a cross sectional study. Afr Health Sci 2019;19(1):1607–16.
Sulaiman MK. Diabetic nephropathy: recent advances in pathophysiology and challenges in dietary management. Diabetol Metab Syndr 2019;11:7.
Thakur SK, Dhakal SP, Parajuli S, Sah AK, Nepal SP, Paudel BD. Microalbuminuria and Its Risk Factors in Type 2 Diabetic Patients. J Nepal Health Res Counc 2019;17(1):61–5.
Martin M, Edrisa M, SSinabulya I, Samuel K, Frank M, Kiiza MC. Microalbuminuria among Newly Diagnosed Diabetic Patients at Mulago National Referral Hospital in Uganda: A Cross Sectional Study. J Obes Weight Loss Medicat 2018;4(1):021.
Sarafidis PA, Bakris GL. Microalbuminuria and chronic kidney disease as risk factors for cardiovascular disease. Nephrol Dial Transplant 2006;21(9):2366–74.
American Diabetes Association. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2020. Diabetes Care 2020;43(Suppl 1):S14–31.
Ahmad T, Ulhaq I, Mawani M, Islam N. Microalbuminuria in Type-2 Diabetes Mellitus; the tip of iceberg of diabetic complications. Pak J Med Sci 2017;33(3):519–23.
Arun CS, Stoddart J, Mackin P, MacLeod JM, New JP, Marshall SM. Significance of microalbuminuria in long-duration type 1 diabetes. Diabetes Care 2003;26(7):2144–9.
Sinkala M, Zulu M, Kaile T, Simakando M, Chileshe C, Kafita D, et al. Performance Characteristics of Kidney Injury Molecule-1 In Relation to Creatinine, Urea, and Microalbuminuria in the Diagnosis of Kidney Disease. Int J Appl Basic Med Res 2017;7(2):94–9.
Kiconco R, Rugera SP, Kiwanuka GN. Microalbuminuria and Traditional Serum Biomarkers of Nephropathy among Diabetic Patients at Mbarara Regional Referral Hospital in South Western Uganda. J Diabetes Res 2019;2019:3534260.
Afkhami-Ardekani M, Modarresi M, Amirchaghmaghi E. Prevalence of microalbuminuria and its risk factors in type 2 diabetic patients. Indian J Nephrol 2008;18(3):112–7.
Huang X, Zhou Y, Xu B, Sun W, Lin L, Sun J, et al. Glycated haemoglobin A1c is associated with low-grade albuminuria in Chinese adults. BMJ Open 2015;5(8):e007429.
Mahgoub S, Youns M, Bassyouni A, Hassan Z. Serum levels of heat shock protein 27 as a potential marker of diabetic nephropathy in Egyptians with type 2 diabetes. J Appl Pharm Sci 2012;2(11):14–20.
Seymour H, Gilman D, Quin J. Severe ketoacidosis complicated by ‘ecstasy’ingestion and prolonged exercise. Diabet Med 1996;13(10):908–9.
Jakhotia S, Sivaprasad M, Shalini T, Reddy PY, Viswanath K, Jakhotia K, et al. Circulating levels of Hsp27 in microvascular complications of diabetes: prospects as a biomarker of diabetic nephropathy. J Diabetes Complications 2018;32(2):221–5.
Irfan M, Ahmed S, Ramzan A, Wasee N, Zia N, Anjum N. Evaluation of Heat Shock Protein-27 levels as a predictor of diabetic nephropathy in early diabetics. Ann Abbasi Shaheed Hosp Karachi Med Dent Coll 2021;26(3):121–6.
Gruden G, Bruno G, Chaturvedi N, Burt D, Schalkwijk C, Pinach S, et al. Serum heat shock protein 27 and diabetes complications in the EURODIAB prospective complications study: a novel circulating marker for diabetic neuropathy. Diabetes 2008;57(7):1966–70.
Tikoo K, Meena R, Kabra D, Gaikwad A. Change in post‐translational modifications of histone H3, heat‐shock protein‐27 and MAP kinase p38 expression by curcumin in streptozotocin‐induced type I diabetic nephropathy. Br J Pharmacol 2008;153(6):1225–31.
Pourhamidi K, Dahlin LB, Boman K, Rolandsson O. Heat shock protein 27 is associated with better nerve function and fewer signs of neuropathy. Diabetologia 2011;54(12):3143–9.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Muhammad Irfan, Fatima Abid, Arfa Azhar, Mohammad Umair Farooqui, Urooj Fatima, Muhammad Subhan Siddiqui
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.