A FATAL CASE OF PERSISTENT BURKHOLDERIA PSEUDOMALLEI BACTERAEMIA WITH SEVERE PNEUMONIA AND SPLENIC ABSCESS

Authors

  • Chee Yik Chang Medical Department, Hospital Sungai Buloh, Selangor-Malaysia
  • Hui Ling Lee Medical Department, Hospital Sungai Buloh, Selangor-Malaysia

DOI:

https://doi.org/10.55519/JAMC-02-11131

Keywords:

Melioidosis, Burkholderia pseudomallei, necrotizing pneumonia, splenic abscesses

Abstract

Burkholderia pseudomallei is a Gram-negative bacterium that causes melioidosis. Melioidosis is a potentially fatal disease that is endemic in Southeast Asia and Northern Australia, and is being increasingly recognized in other regions worldwide. Melioidosis can affect any organ system and present with a wide range of clinical manifestations including pneumonia, bone, skin/soft tissue, or central nervous system infections. In this report, we describe a diabetic farmer who succumbed to persistent B. pseudomallei bacteraemia with multiorgan involvement despite treatment with meropenem and ceftazidime.

Author Biography

Hui Ling Lee, Medical Department, Hospital Sungai Buloh, Selangor-Malaysia

Medical Department, Hospital Sungai Buloh, Selangor-Malaysia

References

Hoffmaster AR, AuCoin D, Baccam P, Baggett HC, Baird R, Bhengsri S, et al. Melioidosis diagnostic workshop, 2013. Emerg Infect Dis 2015;21(2):e141045.

Cheng AC, Currie BJ. Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev 2005;18(2):383–416.

Chang CY, Lau NLJ, Currie BJ, Podin Y. Disseminated melioidosis in early pregnancy - an unproven cause of foetal loss. BMC Infect Dis 2020;20(1):201.

Suputtamongkol Y, Chaowagul W, Chetchotisakd P, Lertpatanasuwun N, Intaranongpai S, Ruchutrakool T, et al. Risk factors for melioidosis and bacteremic melioidosis. Clin Infect Dis 1999;29(2):408–13.

Currie BJ. Melioidosis: an important cause of pneumonia in residents of and travellers returned from endemic regions. Eur Respir J 2003;22(3):542–50.

Chang CY. Pulmonary melioidosis. QJM 2022;114(12):900.

Khiangte HL, Robinson Vimala L, Veeraraghavan B, Yesudhason BL, Karuppusami R. Can the imaging manifestations of melioidosis prognosticate the clinical outcome? A 6-year retrospective study. Insights Imaging 2019;10(1):17.

Currie BJ, Fisher DA, Howard DM, Burrow JN, Lo D, Selva-Nayagam S, et al. Endemic melioidosis in tropical northern Australia: a 10-year prospective study and review of the literature. Clin Infect Dis 2000;31(4):981–6.

Limmathurotsakul D, Wuthiekanun V, Wongsuvan G, Pangmee S, Amornchai P, Teparrakkul P, et al. Repeat blood culture positive for B. pseudomallei indicates an increased risk of death from melioidosis. Am J Trop Med Hyg 2011;84(6):858–61.

Chantratita N, Rholl DA, Sim B, Wuthiekanun V, Limmathurotsakul D, Amornchai P, et al. Antimicrobial resistance to ceftazidime involving loss of penicillin-binding protein 3 in Burkholderia pseudomallei. Proc Natl Acad Sci U S A 2011;108(41):17165–70.

Apisarnthanarak P, Thairatananon A, Muangsomboon K, Lu DS, Mundy LM, Apisarnthanarak A. Computed tomography characteristics of hepatic and splenic abscesses associated with melioidosis: a 7-year study. J Med Imaging Radiat Oncol 2011;55(2):176–82.

Yik CC. Ruptured splenic abscess and splenic vein thrombosis secondary to melioidosis: A case report. J Acute Dis 2020;9:89–92.

Downloads

Published

2023-04-17