ELUCIDATING THE MASKED DIAGNOSIS- GLILD MASQUERADING AS ASTHMA EXACERBATIONS IN A CVID PATIENT
Abstract
We present the case of a young woman with Common Variable Immunodeficiency (CVID) whose underlying Granulomatous Lymphocytic Interstitial Lung Disease (GLILD) was repeatedly misdiagnosed as asthma exacerbations. The diagnostic delay led to multiple emergency visits and hospital admissions. This report underscores the diagnostic challenge of GLILD, its clinical and radiologic overlap with asthma and infections, and highlights the need for a high index of suspicion in CVID patients with persistent respiratory symptoms and diffuse pulmonary findings.
References
1. Park JH, Levinson AI. Granulomatous-lymphocytic interstitial lung disease (GLILD) in common variable immunodeficiency. Clin Immunol 2010;134(2):97–103.
2. Martelius T, Seppänen MRJ. Glimpses into treating GLILD. J Allergy Clin Immunol 2023;152(2):365–7.
3. Bernard F. Common variable immunodeficiency-associated granulomatous and lymphocytic interstitial lung disease (GLILD): state of the art [Master’s thesis]. [Internet]. Coimbra: Universidade de Coimbra; 2012. [cited 2025 Jan]. Available from: https://hdl.handle.net/10316-97861
4. Galant-Swafford J, Catanzaro J, Achcar RD, Cool C, Koelsch T, Bang TJ, et al. Approach to diagnosing and managing granulomatous-lymphocytic interstitial lung disease. EClinicalMedicine 2024;75:102749.
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Mehr Ali Khan
This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.
