A A CASE OF CENTRAL NERVOUS SYSTEM INVASIVE ASPERGILLOSIS MIMICKING ORBITAL CELLULITIS IN A PATIENT WITH UNCONTROLLED TYPE 2 DIABETES MELLITUS AND END-STAGE RENAL DISEASE
Abstract
Central nervous system aspergillosis is a rare and often fatal complication seen in immunocompromised individuals. Here, we present the case of a 60-year-old female with uncontrolled type 2 diabetes mellitus and end-stage renal disease (ESRD) who was ultimately diagnosed with CNS aspergillosis. This case underscores the diagnostic challenge and delays posed by fungal infections in patients with predisposing conditions, necessitating a multidisciplinary approach for timely diagnosis and management.
References
1. Sharma RR, Pawar SJ, Lad SD, Mishra GP, Netalkar AS, Rege S. Fungal infections of the central nervous system. In: Quiñones-Hinojosa A, editor. Schmidek and Sweet Operative Neurosurgical Techniques. 6th ed. Philadelphia: W.B. Saunders: 2012; p.1691–732.
2. Patiroglu T, Unal E, Karakukcu M, Ozdemir MA, Tucer B, Yikilmaz A, et al. Multiple fungal brain abscesses in a child with acute lymphoblastic leukemia. Mycopathologia 2012;174(6):505–9.
3. Hamill RJ. Fungal infections of the central nervous system. In: Anaissie EJ, McGinnis MR, Pfaller MA, editors. Clinical Mycology. 2nd ed. Edinburgh: Churchill Livingstone: 2009; p.591–607.
4. Candoni A, Klimko N, Busca A, Cesaro S, Caira M, Garcia-Vidal C, et al. Fungal infections of the central nervous system and paranasal sinuses in onco-haematologic patients: epidemiological study reporting the diagnostic-therapeutic approach and outcome in 89 cases. Mycoses 2019;62(3):252–60.
5. Pasqualotto AC, Denning DW. Post-operative aspergillosis. Clin Microbiol Infect 2006;12(10):1060–76.
6. Miceli MH. Central nervous system infections due to Aspergillus and other hyaline molds. J Fungi (Basel) 2019;5(3):E65.
7. Walsh TJ, Anaissie EJ, Denning DW, Herbrecht R, Kontoyiannis DP, Marr KA, et al. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis 2008;46(3):327–60.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Zomer Sardar, Azhar Nasim, Mohammad Faisal, Mariam Danish Iqbal

This work is licensed under a Creative Commons Attribution-NoDerivatives 4.0 International License.
Journal of Ayub Medical College, Abbottabad is an OPEN ACCESS JOURNAL which means that all content is FREELY available without charge to all users whether registered with the journal or not. The work published by J Ayub Med Coll Abbottabad is licensed and distributed under the creative commons License CC BY ND Attribution-NoDerivs. Material printed in this journal is OPEN to access, and are FREE for use in academic and research work with proper citation. J Ayub Med Coll Abbottabad accepts only original material for publication with the understanding that except for abstracts, no part of the data has been published or will be submitted for publication elsewhere before appearing in J Ayub Med Coll Abbottabad. The Editorial Board of J Ayub Med Coll Abbottabad makes every effort to ensure the accuracy and authenticity of material printed in J Ayub Med Coll Abbottabad. However, conclusions and statements expressed are views of the authors and do not reflect the opinion/policy of J Ayub Med Coll Abbottabad or the Editorial Board.
USERS are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.
AUTHORS retain the rights of free downloading/unlimited e-print of full text and sharing/disseminating the article without any restriction, by any means including twitter, scholarly collaboration networks such as ResearchGate, Academia.eu, and social media sites such as Twitter, LinkedIn, Google Scholar and any other professional or academic networking site.



