SYSTEMIC LUPUS ERYTHEMATOSUS COMPLICATED WITH CASTLEMAN DISEASE : A CASE REPORT

Authors

  • Ahsan Khurshid Quaid-e-Azam Medical College/Bahawal Victoria Hospital, Bahawalpur
  • Anum Abbas Quaid-e-Azam Medical College/Bahawal Victoria Hospital, Bahawalpur
  • Suhail Iqbal Quaid-e-Azam Medical College/Bahawal Victoria Hospital, Bahawalpur
  • Raheel Khan Quaid-e-Azam Medical College/Bahawal Victoria Hospital, Bahawalpur

Keywords:

Castleman Disease, Systemic Lupus Erythematosus, Lupus Nephritis, Autoimmune, Lymphoproliferative

Abstract

Castleman disease is a rare nonclonal heterogeneous group of diseases involving lymphoid tissue. It often simulates other inflammatory conditions and malignancies. Systemic lupus erythematosus, being a multisystem inflammatory disorder, shares many features with Castleman disease. Here, we report a similar case of a middle age female who was initially diagnosed as SLE with lupus nephritis, for which she was put on steroids and immunosuppressants. After commencing treatment, her symptoms resolved and she remained in remission for some period. However, her condition was complicated with Castleman disease later on. For diagnostic and therapeutic purpose, she underwent lymph node resection and to our surprise, her condition improved.

References

Demirkan FG, Doğan S, Kalyoncu Uçar A, Sönmez HE, Aktay Ayaz N. Systemic lupus erythematosus complicated with Castleman disease: a case-based review. Rheumatology international. 2021 Feb;41(2):475-9.

Fajgenbaum DC, Uldrick TS, Bagg A, Frank D, Wu D, Srkalovic G, Simpson D, Liu AY, Menke D, Chandrakasan S, Lechowicz MJ. International, evidence-based consensus diagnostic criteria for HHV-8-negative/idiopathic multicentric Castleman disease. Blood, The Journal of the American Society of Hematology. 2017 Mar 23;129(12):1646-57.

Wang L, Chen H, Shi J, Tang H, Li H, Zheng W, et al. Castleman disease mimicking systemic lupus erythematosus: A case report. Medicine (Baltimore). 2018;97(38):e12291.

L.S. Cross, A. Aslam, S.A. Misbah, Antinuclear antibody-negative lupus as a distinct diagnostic entity-does it no longer exist?, QJM: An International Journal of Medicine, Volume 97, Issue 5, May 2004, Pages 303-308, https://doi.org/10.1093/qjmed/hch048

Gunathilake K, Rifath M, Munasinghe B, Muhunthiny P, Vincent G. Systemic lupus erythematosus mimicking idiopathic multicentric Castleman disease: A diagnostic dilemma. SAGE Open Medical Case Reports. 2022;10:2050313X221106110.

Soumerai JD, Sohani AR, Abramson JS. Diagnosis and management of Castleman disease. Cancer control. 2014 Oct;21(4):266-78.

Dispenzieri A, Fajgenbaum DC. Overview of Castleman disease. Blood, The Journal of the American Society of Hematology. 2020 Apr 16;135(16):1353-64.

Zhou T, Wang HW, Pittaluga S, Jaffe ES. Multicentric Castleman disease and the evolution of the concept. Pathologica. 2021 Oct;113(5):339.

Ma X, Li J, Fan L, Jiang H, Shi G, Ge D, et al. Systemic lupus erythematosus combined with Castleman disease and secondary paraneoplastic pemphigus: a case report. Pediatric Rheumatology. 2023;21(1):126.

González García A, Fernández-Martín J, Robles Marhuenda Ã. Idiopathic multicentric Castleman disease and associated autoimmune and autoinflammatory conditions: practical guidance for diagnosis. Rheumatology. 2023 Apr 1;62(4):1426-35.

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Published

2026-01-14

How to Cite

1.
Khurshid A, Abbas A, Iqbal S, Khan R. SYSTEMIC LUPUS ERYTHEMATOSUS COMPLICATED WITH CASTLEMAN DISEASE : A CASE REPORT. J Ayub Med Coll Abbottabad [Internet]. 2026 Jan. 14 [cited 2026 Jan. 19];37(3):394-6. Available from: https://www.jamc.ayubmed.edu.pk/index.php/jamc/article/view/13107

Issue

Vol. 37 No. 3 (2026): JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD

Section

CASE REPORT

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Copyright (c) 2026 Ahsan Khurshid, Anum Abbas, Suhail Iqbal, Raheel Khan

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