ZIKA VIRUS INFECTION; VERTICAL TRANSMISSION AND FETAL CONGENITAL ANOMALIES

Authors

  • Aziz-un-Nisa Abbasi

Abstract

Zika virus (ZIKV) is an arbovirus belonging to flaviviridae family that includes Dengue, West Nile, and Yellow Fever among others. Zika virus was first discovered in 1947 in Zika forest of Uganda. It is a vector borne disease, which has been sporadically reported mostly from Africa, Pacific islands and Southeast Asia since its discovery. ZIKV infection presents as a mild illness with symptoms lasting for several days to a week after the bite of an infected mosquito. Majority of the patients have low grade fever, rash, headaches, joints pain, myalgia, and flu like symptoms. Pregnant women are more vulnerable to ZIKV infection and serious congenital anomalies can occur in foetus through trans-placental transmission. The gestation at which infection is acquired is important. ZIKA virus infection acquired in early pregnancy poses greater risk. There is no evidence so far about transmission through breast milk. Foetal microcephaly, Gillian Barre syndrome and other neurological and autoimmune syndromes have been reported in areas where ZIKA outbreaks have occurred. As infection is usually very mild no specific treatment is required. Pregnant women may be advised to take rest, get plenty of fluids. For fever and pain they can take antipyretics like paracetamol. So far no specific drugs or vaccines are available against ZIKA Virus Infection so prevention is the mainstay against this diseases. As ZIKV infection is a vector borne disease, prevention can be a multi-pronged strategy. These entail vector control interventions, personal protection, environmental sanitation and health education among others.

References

Lanciotti RS, Kosoy OL, Laven JJ, Velez JO, Lambert AJ, Johnson AJ, et al. Genetic and serologic properties of Zika virus associated with an epidemic, Yap State, Micronesia, 2007. Emerg Infect Dis 2008;14(8):1232–9.

Cao-Lormeau VM, Roche C, Teissier A, Robin E, Musso D, Berry AL, et al. Zika Virus, French Polynesia, South Pacific, 2013. Emerg Infect Dis 2014;20(6):1085–6.

Health protection-guidance. ZIKA Virus. [Internet]. [cited 2016 Jan 15]. Available from https://www.gov.uk/guidance/zika-virus

CDC. Zika Symptoms, Diagnosis, & Treatment. [Internet]. [cited 2016 Jan 10]. Available from: http://www.cdc.gov/zika/index.html

Duffy MR, Chen TH, Hancock WT, Powers AM, Kool JL, Lanciotti RS, et al. Zika Virus outbreak on Yap. Island, Federated States of Micronesia. N English J Med 2009;360(24):2536–43.

Hayes EB .ZIKA Virus outside Africa. Emerg lnfect Dis 2009;15(9):1347–50.

Musso D, Roche C, Robin E, Nhan T, Teissier A, Cao-Lormeau VM. Potential Sexual transmission of ZIKA Virus. Emerg lnfect Disc 2015;21(2):359–62.

CDC. Areas with Zika. [Internet]. [cited 2016 Jan 10]. Available from: http://www.cdc.gov/zika/geo/index.html

Zika Virus. CDC [Internet]. [cited 2016 Jan 15]. Available from: http://www.cdc.gov/zika/index.html

WHO. PAHO Statement on Zika Virus Transmission and Prevention [Internet]. [cited 2016 Feb 5]. Available from: http://www.paho.org/hq/index.php?option=com_content&view=article&id=11605&Itemid=41716&lang=en

Oeler E, Watrin l, large P, Leparc-Goffart I, Lastere S, Valour F, et al. ZIKA Virus Infection complicated by Guillain-Barre syndrome case report,French Polynesia, December 2013. Euro Surveill 2014;19(9):4–6.

WHO. Epidemiological Update: Neurological syndromes, congenital anomalies and ZIKA Virus Infection. 17 January, Washington DC: PAHO/WHO;2016.

WHO. Zika Virus Microcephaly And Guillain-Barré Syndrome; Situation Report 26 February 2016. [Internet]. [cited 2016 Feb 5]. Available from: http://www.who.int/emergencies/zika-virus/situation-report-26-02-2016.pdf

Peterson EE, Staples JE, Meaney-Delman D, Fischer M, Ellington SR, Callaghan WM, et al. Interim Guidelines for Pregnant Women During a ZIKA Virus outbreak -United States, 2016. MMWR Morb Mortal Wkly Rep 2016;65(2):30–3.

CDC. Avoid bug bites. [Internet]. [cited 2016 Jan 15]. Available from: http://wwwnc.cdc.gov/travel/page/avoid-bug-bites

Published

2016-03-10

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