A STUDY OF RELATIONSHIP OF ABO BLOOD GROUPS WITH MYOCARDIAL INFARCTION AND ANGINA PECTORIS

ISRAR AHMED AKHUND, IRSHAD ALI ALVI, ASMAT KAMAL ANSARI, Muhammad Azhar Mughal, Anwar Ali Akhund

Abstract


Background: This is a comprehensive report that has determined the occurrence of Myocardial infarction and Angina pectoris in
"ABO" blood group system among patients with coronary artery disease in some areas of Sindh province of Pakistan. Methods:
Three hundred patients with Coronary Disease (CAD) were selected from cardiology wards of LMC hospital Hyderabad, DMC
hospital Karachi and PMC hospital Nawabshah. The patients were separated into two categories: myocardial infarction and angina
pectoris. The patients with old myocardial infarction were also included. A careful history was taken, suggesting myocardial
infarction (MI) or angina from a standard WHO (Rose) chest pain, and an electrocardiogram showing evidence of possible
myocardial infarction and angina, and the patient's recall of a doctor's diagnosis of M.I or angina. ABO blood grouping of above
patients was done by simple agglutination method. Results: The blood group "A" was the commonest among myocardial infarction
and angina pectoris patients while these diseases were least in blood group "O" patients. Conclusions: This comparison shows the
existence of a direct relation between blood group antigens and coronary artery disease. It is therefore of great importance for future
genetic studies, as present report and our previous studies give clear picture of excess and deficit of CAD in particular blood groups
of "ABO" system. This may be due to some special genetic makeup

References


Akhund I A. Alvi I.A. Hafeezullah and Ansari A K ABO blood

groups in relation to ischemic heart disease. IAMC. 1998. Vol-

No. 114-15

Akhund I A. Alvi I.A. I Hafeezullah and Ansari A.K Blood

groups and serum lipids in patients with ischemic hear!

disease, /AMC. 1998. Vol-10 No 214-18 Whincup IKJC.

Phillips A N. Shaper A O ABO blood groups and Ischemic

heart disease in British Men B.M J. 1990: 1679-1682

Njoku. Ononoghu LC. Almunan E.O. Nwanjho .1. Scrum v

lipids. ABO blood groups and sickle cell trait. Indian 1. B

Physiol. Pharmacol. 1996: 10:171-4.

Meade T.W. Cooper J A. -Stirling Y. Factor VIII. AM) blood

groups and the incidence of ischemic heart disease. Br. J.

Haematology, 1994: 88:601-7.

Tarjan - Z. Tonelli M. Duba., J. or and i - A Correlation 9

between ABO and Rh blood groups, scrum cholesterol and

ischemic heart disease in patients undergoing coronarography.

Orv Hetil; 1995; 156(5). 767-769 Allan T.M, Dawson A.A:

ABO blood groups and ischemic heart disease.

Br. Med. J. 1986; 30:377-382.

Havlik. R.J. Feinleib. M. Garrison R.J. & Kannel WB Blood

groups and coronary heart disease. I.ancet, 1969 II 269-270.

Shaper A. G. Gook D.G. & Walker M: Prevalence of ischemic

heart disease in middle aged British men. I3r Heart- I J. 1984:

: 595-605.

Shaper A. G. Gook D.G. & Walker M Recall of diagnosis b)

man with ischemic heart disease. Br Heart-.!. 1984. 51 606- a

II

Dacie JV& Lewis SM (1984): In practical Hematology

Churchill Livingstone, Edinburgh

Mourant AL: Kopec AC <& Domaniewska -. Sobzak-K

Thrombosis, hemorrhage, and other disorders of the

circulatory system In Blood groups and diseases. 1978:

Oxford University Press, Bronte-Stewart. B. Botha M C.&

Krut I. II: ABO blood groups in relation to ischemic heart

disease British Med I -1 1962. 1.1646-1650.

Nefzger M.D. Hrubeez. Chalmers T.C Venous 7

Thromboembolism and blood groups. Lancet -1. 1969. 887

Denbrough M.A Blood groups and ischemic heart disease Br.

Med J. 1962: 2 927

Medalie. J H. Levene. C Papier. C Goldbourt U Drefus, F.

Oron D Neufeld H & Kiss I: Blood groups. myocardial

infarction and angina pectoris among 10.000 adults. Nor

England Journal of Medicine 1971.285 1348-1353

Khaskheh D K Akhund A. A, Qureshi A H Distribution of j

ABO and Rhesus blood groups in The residents of. Sindh P 1

Health, 1994.31-45-50 ,

Hussain A Shaikh S a Haider M. Rashied I. Malik MR a

frequency distribution of ABO and Rhesus blond groups in

population of Baluchistan PAFM.J 2001.Vol 51 No 1 12-26


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