Aziz Gul Mufti, Farhat Abbas


Infective endocarditis (IE) is a disease in which the
infecting organism invades the endothelial lining of
the heart and great vessels.1
Historically IE has been classified as acute or subacute on the basis of clinical course in the preantibiotic era. Acute endocarditis denotes infection on
a normal valve by a highly virulent organism causing
rapid destruction of the heart valves and widespread
metastatic foci. Death usually occurred within six
weeks. Subacute endocarditis referred to infection on
an abnormal valve (usually rheumatic) with relatively
avirulent organism. The course was indolent i.e. upto
two years.
Currently rheumatic heart disease is becoming
infrequent, especially in western countries, a newer
classification has been adopted.
1. Native Valve Endocarditis (NVE).
2. Prosthetic Valve Endocarditis (PVE).
3. I/V drug abuser endocarditis.

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