OCTREOTIDE IN THE MANAGEMENT OF ENTEROCUTANEOUS FISTULAE

Authors

  • Tariq S. Mufti
  • Mohammad Akbar
  • Khalid Khan

Abstract

Efficacy of Octreotide (Somatostatin) in the conservative management ofpostoperative Enterocutaneous fistula was studied in seven patients with ageranging 1 to 70 years. Four out of seven fistulae closed within 21 days ofstarting the drug. One case, where fistula took over a month to close,responded well in reducing the output significantly within 10 days of startingtherapy. The cases and the results are discussed. Favourable results followingOctreotide therapy in this study need strengthening by further studies.

References

Aguire A, et al. The role of surgery and hyper -

alimentation in therapy of gastrointestinal cutaneous

fistulae. Annals of Surg. 1194, 180: 393- 401.

Borison DI, et al. Treatment of Enterocutaneous and

Colocutaneous fistulae with early surgery and

Somatostatin analog. Dis. Col. Rec. 1992, 35: 635- 8.

Boike GM. Treatment of small intestinal fistula with

Octreotide, a Somatostatin analog. J. Surg. Oncol. 1992,

: 444-5.

Dicastanzo J et al. Somatostatin in persistent

gastrointestinal fistula treated by TPN. Lancet 1982, ii:

-339.

El-Bahar T & Irving M. Intestinal Fistulas. Recent

Advances in Surgery, 13, 1990; 103-124.

Hild P et al. Conservative treatment of fistulas of

pancreas and small intestine with Somatostatin. Ann.

Chir. 1982, 3: 193-196.

Harris GA. The role of Somatostatin and Somatostatin

analogs in the management of gastrointestinal disease.

Current Medical Literature, 1993: 40-42, London.

Irving M & Beadle C. External Intestinal Fistulas.

Clinics in Gastroenterology, 11: 327-336.

Kovacs HA, et al. Treatment of a chronic Gastro

cutaneous fistula with Octreotide in a pediatric patient.

; 15: A112 (Abs.685)

Nabiola-Calong P, et al. Blind evaluation of the efficacy

of Octreotide, a Somatostatin analog, on small bowel

fistula output. Lancet, 1987: 2: 672-3.

Nabiola P, et al. Treatment of 27 Enterocutaneous

fistulas with a half-life Somatostatin analog (SMS 201-

. Ann. Surg. 1989, 210: 56-58.

Ray-Jade C, et al. Octreotide in the management of postoperative Enterocutaneous fistulas and stress ulcer

bleeding. Am. J. Gastroenterol. 1992, 87: 1212-1215.

Sbanbhogue LKR, et al. Parenteral nutrition in the

surgical patient. Br. J. Surg. 1987, 74: 172-180.

Zera RT, et al. Enterocutaneous fistulas. Effect of TPN

and surgery. Dis. Col. Rec. 1983, 26: 109- 112.

Most read articles by the same author(s)

1 2 > >>