EFFECT OF ALLOXAN — INDUCED DIABETES ON SERUM ELECTROLYTES AND LIPIDS IN RABBITS

Authors

  • Muhammad Shafique
  • Misbahul Ain Khan
  • Amjad M. Chughtai
  • Akbar Ali Kahloon
  • Iqbal Ahmad Khan

Abstract

ABSTRACT:Effect of alloxan on scrum glucose, electrolytes and lipids was observed in 20 induceddiabetic rabbits. Thirteen days after alloxan administration sufficient hyperglycemia was detected andthe serum levels of magnesium and sodium were lower significantly. Out of 20, eight Rabbits (40%)developed marked hypomagnesemia and hyponatremia which were inversely associated with thedegree of hyperglycemia. Serum HDL-cholesterol was also decreased and triglycerides increasedstatistically. However, the difference in the mean values of total cholesterol, calcium and potassiumwere found to be non-significant after alloxan injection.

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