COMPARISON OF LIPID PROFILE AND APOPROTEIN IN SEDENTARY WORKERS AND THOSE INVOLVED IN REGULAR EXERCISE
Abstract
Background: One of the important effects of exercise on human body is on the metabolic systemespecially on lipids; elevated lipids and lipoprotein are risk factors for coronary heart disease. Thiscase-control study was conducted t o compare the lipid profile and apo-protein B levels insedentary workers and subjects involved in regular exercise. Methodology: The study wasconducted at Women Medical College Abbottabad, from July 2004 to January 2005. Subjectswere civilians and army men involved in regular exercise for more than 6 months duration (testgroup) and sedentary workers (control group). The age, body weight, height, waist hip ratio andother related findings were recorded on a special proforma. Fasting blood samples were taken andwere analyzed for lipid profile and apoprotein B levels. Statistical analysis was done by the Chisquare and the S tudent t tests and level of significance was recorded. Result: The subjectscomprised 29 army men, 24 civilians and 39 sedentary workers. Significant differences werefound between the control and test groups for WHR, total cholesterol, HDL, LDL, Triglycerides,Apo B, and Cholesterol/HDL ratio; in addition the civilian group also showed significantdifferences from the control group in BMI values. Although LDL levels were lower in army thansedentary group, the difference was statistically nonsignificant. Significant differences were foundbetween the army and civilian groups in age, HDL, Triglycerides and Apo B values. Conclusion:Long term aerobic exercise has beneficial effects in decreasing Apo- protein B levels, LDL levelsand total cholesterol /HDL ratio. Exercise habits should be encouraged in general population todecrease the cardiovascular disease risk.Key Words: Exercise, lipid profile, apo-lipoprotein B.References
Sinderman AD, Pedersen T, Kjekshus J. Putting low-density
lipoprotein at centre stage in atherogenesis. Am J Cardiol.
; 79: 64-67.
Havel RJ, Goldstein JL, Brown MS. Lipoproteins and lipid
transport. In: Bondy CPIC, Rosenberg LE, eds. Metabolic
control and disease. Philadelphia: WB Saunders; 1980: 393-
Gordon DJ, Probstfield JL, Garrison RJ, et al. High-density
lipoprotein cholesterol and cardiovascular disease: four
prospective American studies. Circulation. 1989; 79: 8–15.
Saku K, Zhang B, Ohta T, et al. Quantity and function of
high density lipoprotein as an indicator of coronary
atherosclerosis. J Am Coll Cardiol. 1999; 33: 436–443.
Patsch JR, Gotto AM Jr, Olivercrona T, et al. Formation of
high density lipoprotein 2-like particles during the lipolysis
of very low density lipoprotein in vitro. Proc Nat Acad Sci U
S A. 1978; 75: 4519–4523.
Warnick GR. Measurement and clinical significance of highdensity lipoprotein cholesterol subclasses. In: Rifai M,
Warnick GR, Dominiczak MH, eds. Handbook of
Lipoprotein Testing. Washington DC: AACC Press; 1997:
–266.
Durstine JL, Haskell WL. Effects of exercise training on
plasma lipids and lipoproteins. Exerc Sport Sci Rev. 1994;
: 477–521.
Stefanick ML, Wood PD. Physical activity and lipoproteins
metabolism and lipid transport.In: Bouchard C, Shephard RJ,
Stephens T, eds. Physical Activity, Fitness and Health:
International Proceedings and Consensus Statement.
Champaign, IL: Human Kinetics; 1994: 417–431.
Thompson PD, Yurgalevitch SM, Flynn MM, et al. Effect of
prolonged exercise training without weight loss on highdensity lipoprotein metabolism in overweight men.
Metabolism. 1997; 46: 217–223.
Leon AS. Effects of exercise conditioning on physiological
precursors of coronary heart disease. J Cardiopulmon Rehab.
; 11: 46–57.
Shephard RJ, Balady GJ. Exercise as cardiovascular therapy.
Circulation. 1999; 99: 963–972.
Krummel D, Etherton TD, Peterson S, et al. Effects of
exercise on plasma lipids and lipoproteins of women. Proc
Soc Exp Biol Med. 1993; 204: 123–137.
J Ayub Med Coll Abbottabad 2001; 18(4)
Leon AS, Sanchez OA. Response of blood lipids to exercise
training alone or combined with dietary intervention. Med
Sci Sports Exerc. 2001; 33 (suppl 6): S502–S515.
Mitchell BD, Kammerer CM, Blangero J, et al. Genetic and
environmental contributions to cardiovascular risk factors in
Mexican Americans: the San Antonio family heart study.
Circulation. 1996; 94: 2159–2170.
Khan AS, Mustafa G, Ali H, Study of lipid profile in acute
myocardial infarction. Pak Heart Journal 1987;20(3):49-52.
Buyukyazi G. Differences in blood lipids and apolipoproteins
between master athletes, recreational athletes and sedentary
men. J Sports Med Phys Fitness 2005; 45(1):112-20.
Lippi G, Schena F, Salvagno GL, Montagnana M, Ballestrieri
F, Guidi GC. Comparison of the lipid profile and
lipoprotein(a) between sedentary and highly trained subjects.
Clin Chem Lab Med 2006;44(3):322-6.
Oyelola OO, Rufai MA. Plasma lipid, lipoprotein and
apolipoprotein profiles in Nigerian university athletes and
non-athletes. Br J Sports Med 1993 Dec;27(4):271-4.
Marti B, Suter E, Riesen WF, Tschopp A, Wanner HU,
Gutzwiller F. Effects of long-term, self-monitored exercise
on the serum lipoprotein and apolipoprotein profile in
middle-aged men. Atherosclerosis 1990;81(1):19-31.
Yalin S, Gok H, Tokso Z. The effects of the short -term
regular exercise-diet programe on lipid profile in sedentary
subjects. Anadolu Kardiyol Derg 2001 Sep;1(3):179-80.
Lamarche B, Moorjani S, Lupien PJ, et al. Apolipoprotein A-
and B levels and the risk of ischemic heart disease during a
five- year follow-up of men in the Quebec cardiovascular
Study. Circulation 1996; 94:273-78.
Durrington PN. Can measurement of apolipoprotein B
replace the lipid profile in the follow-up of patients with
lipoprotein disorders? Clin Chem 2002; 48:401-402.
Ballantyne CM, Andrews TC, Hsia JA, Kramer JH, Shear C.
Correlation of non-high-Density lipoprotein cholesterol with
apolipoprotein B: effect of 5-hydroxymethylglutaryl
coenzyme A reductase inhibitors on non-high-density
lipoprotein cholest erol levels. Am J Cardiol 2001; 88: 265-
Sinderman AD, Furberg CD, Keech A, Roeters van Lennep
JE, Frohilich J, Jungner I, Wallidius G. Apolipoprotein
versus lipid as indices of coronary risk and as targets for
statin treatment. The Lancet 2003;361:777-80.
Tokmakidis SP, Volaklis KA. Training and detraining effects
of a combined-strength and aerobic exercise program on
blood lipids in patients with coronary artery disease. J
Cardiopulm Rehabil 2003;23(3):193-200.
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