Rustam Khan, Shahab Abid, Saeed Hamid, Zaigham Abbas, Hasnain Shah, Wasim Jafri


Background: This study was carried out to evaluate and compare the outcome of various causes
of non-malignant lesions of the esophagus after endoscopic therapeutic intervention. Methods: A
cohort of patients with non-malignant dysphagia presenting at Aga Khan University hospital, a
tertiary care setting who underwent endoscopic intervention was studied. Response to treatment
was evaluated by improvement in dysphagia score on a scale of 0-4 and weight gain. Results: 99
subjects (53 males) were included. Mean age was 48.6±17.2 years. Dysphagia for solids was
present in 48%, for liquids in 3% and for both in 49% patients. Significant weight loss (>10%
body weight) occurred in 35 (35.3%) patients. Achalasia was diagnosed in 49.5%, peptic stricture
in 30.4%, post sclerotherapy stricture in 12.1%, corrosive injury in 4%, post-operative stricture in
4%. In comparative analysis of achalasia and inflammatory groups, good response to dysphagia
was seen in 40/49 (82%) and 22/50 (44%) respectively p < 0.001. Weight gain was 35/49 (72%)
and 22/50 (44%) p <0.001 respectively. Significantly, more endoscopic sessions were required in
inflammatory group compare to achalasia; 2.2 and 1.1 respectively; p <0.001 and 16%
complications rate in inflammatory group comparing to no complications in achalasia.
Conclusions: Dysphagia and weight loss were common presentations in non-malignant
esophageal diseases. Therapeutic intervention in inflammatory group was associated with high
complication than the achalasia group.
Key words: outcome of non-malignant esophageal diseases, Benign esophageal lesions,
Achalasia, esophageal strictures.


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