Shaheen Shah, Huma Shah, Meharun Nissa Khaskheli, Junaid Akhtar


Physicians are often confronted with patients who state that they are “allergic” to a drug. The goal of this review article is to help physicians to develop management plans for patients who present with drug induced diseases. It provides information that allows physicians to differentiate between reactions that are truly allergic in nature and those that are not immunologically mediated. The suggestions which may be helpful in the assessment are discussed and guidance is provided whether a drug may be safely readministered. Unfortunately until we are unable to thoroughly understand the mechanisms responsible for drug induced reactions, our management tools will remain limited.


WHO International drug monitoring: the role of the hospital. Geneva: WHO. 1996.

Rawlins M, Thompson W. Mechanisms of adverse drug reactions. In: Davies D, ed. Textbook of adverse drug reactions. New York: Oxford University Press 1991:18-45.

Park B, Pirmohamed M, Kitteringham N. Idiosyncratic drug reactions: a mechanistic evaluation of risk factors. Br J Clin Pharmacol 1992;34:377-95.

deShazo R, Kemp S. Allergic reactions to drugs and biologic agents. JAMA 1997; 278:1895-1906.

Arky R. In: Sifton D, Westley G, Mazur J, Woerner R, eds. Physician’s desk reference. Montvale: Medical Economics Co, 1999.

Pirmohamed M, Park MS. Idiosyncratic drug reactions: metabolic bioactivation as a pathogenic mechanism. Clin Pharmacokinet 1996;32:215-30.

Hess D, Rieder M. The role of reactive drug metabolites in immune medicated adverse drug reactions. Ann Pharmacother 1997;31:1378-87.


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