INHERITED DYSLIPIDAEMIC DISORDERS CONTRIBUTING TO CORONARY HEART DISEASE
Abstract
Background: Lipoprotein (a) [Lp (a)] is an established independent risk factor for prematuremyocardial infarction (MI)/coronary artery disease (CAD). The study was conducted to determine thevalue of Lp (a) in prediction of CAD or MI in the offspring at risk. Methods: A total of 160 subjectswere investigated. Serum Lp (a) was measured by ELISA, serum total cholesterol, triglycerides (TG)and HDL-Cholesterol by enzymatic colorimetric methods using standard kits. Results: Differences inlevels of total Lp (a) and cholesterol were observed between patients and controls. Both Lp (a)(16.23±1.95 mg/dL) and cholesterol (175.00±7.60 mg/dL) of group A (patients) were higher than thecorresponding controls. However an opposite trend in results was noted for serum HDL-Cholesterol inpatients vs. controls. Conclusion: Persons found to have elevated levels of Lp (a) should focus oncontrolling the known modifiable risk factor for heart disease, especially smoking,hypercholesterolemia, obesity, hypertension and sedentary life style.Keywords: Dyslipidaemia, Coronary Artery Disease, CAD, Lipoprotein (a), MyocardialInfarction, MI, Cholesterol, HDL-Cholesterol, LDL-Cholesterol, TriglyceridesReferences
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