AETIOLOGICAL CONSIDERATIONS OF ACQUIRED APLASTIC ANAEMIA

Saqib Malik, Iram Sarwar, Tariq Mehmood, Farhat Naz

Abstract


Background: Acquired aplastic anaemia is one of the important causes of pancytopenia. This study
was conducted to observe the mode of presentation of acquired aplastic anaemia and to find out its
possible etiological factors. Methods: It is a hospital based descriptive study of 100 patients of
acquired aplastic anaemia. Results: Out of 100 patients 60 were male and 40 female. Majority (44%)
of the patients were between 12–20 years of age. Patient presented with variable symptoms majority
(40%) with fever. Most of the patients had haemoglobin levels between 4–6 gm/dl. (53%). Seventy
percent of the cases had no obvious cause, while in 30% some known causative factors were found.
Chloramphenicol was found to be the most common causative drug. Mortality was 35%. Thirty
patients were partially treated and 15 were lost to follow up. Twenty patients showed improvement
with treatment. Conclusions: Acquired aplastic anaemia is common among males and more
prevalent in younger age group. It is idiopathic in 70% cases while 30% had some cause. It has very
high mortality. Doctors need to keep in mind this fatal condition in patients presenting with anaemia
and should properly investigate before prescribing antibiotics and haematinics.
Keywords: Aplstic anaemia pancytopenia, bone marrow suppression

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