PRIMARY ALVEOLAR PROTEINOSIS

Authors

  • Abdul Rab Khan
  • Aamir Sulaman
  • Munir Ahmad Abbasi
  • Muhammad Jehanzeb

Abstract

A 35 years old man presented with primary pulmonary alveolar proteinosis who was admitted tochest unit of ATH through casualty department. Before he came to our ward he was treated withdifferent antibiotics including anti-tuberculosis drugs for a month at least. But his symptoms didnot improve rather his dyspnoea got worse. He was misdiagnosed till histopathology revealed thathe has pulmonary alveolar proteinosis. With this background we briefly review clinical features,diagnosis and treatment of this rare disease.Keywords: Pulmonary alveolar proteinosis, Dyspnoea, anti-tuberculosis drugs

References

Inove Y, Trapnell BC, Tazwa R, Arai T, Takada T, Hizawa N, et

al, Characteristics of large cohort of patients with autoimmune

pulmonary alveolar proteinosis in Japan. Amj Respir Crit Care

Med 2008;177:752–62.

Seymour JF, presnell JJ. Pulmonary alveolar proteinosis progress

in the first 44 years. Amj Respir crit care Med 2002;166:215–35.

Frazier AA, Franks TJ, Cook Eo, Mohammed TL, Pugatch RD,

Galvin JR. From the archives of AFIP; Pulmonary alveolar

proteinosis Radiographics 2008;28:883–99.

Suratt PM, winn WC Jr, Brody AR, Brody AR, Bolton WK,

Giles RD. Acute silicosis in tomb stone sand blasters. Am Rev

Respir dis 1977;115:521–9.

Doan ML,Guillerman RP, Dishop MK, Nogee LM, Langston C,

Mallory GB, et al. Clinical, radiological and pathological features

of ABCAz mutation in children. Thorax 2008;63:366–73.

Wang BM, Stern EJ, Schmidt RA, Pierson DJ. Diagnosing

pulmonary alveolar proteinosis. A review and an update. Chest

;111:460–6.

Venkateshiah SB, Yan TD, Bonfield TL, Thomassen MJ,

Meziane M, Czich C, et al. An open label trial of granulocyte

macrophage colony stimulating factor therapy for moderate

symptomatic pulmonary alveolar prteinosis. Chest

;130;227–37.

Tazawa R, Trapnell BC, Inoue Y, Arai T, Takada T, Nasuhara Y,

et al. Inhaled Granulocyte/macrophage colony stimulating factor

as therapy for pulmonary alveolar proteinosis. Am J Respi Crit

Care med 2010;181(12):1345–54.

Published

2012-03-01

Most read articles by the same author(s)

1 2 > >>