Shahzad Najeeb, Azhar Munir Qureshi, Anis -ur- Rehman, Fayaz Ahmad, Sher Shah, Asfand Yar Khan, Tahir Saeed Siddiqui


Background: Neonatal seizures (NS) affect approximately 1% of neonates. Clonic, tonic, myoclonic
and subtle seizures are the common types. Birth asphyxia, sepsis, metabolic derangements, intracranial
bleed, kernicterus, tetanus and 5th day fits are the common aetiologies. This study was planned to
evaluate the types and causes of neonatal seizures. Methods: It was a descriptive case series conducted
at Ayub Teaching Hospital, Abbottabad from 12th December 2006 to 25th September 2007 on neonates
having seizures. Serum chemistry, blood counts, cerebrospinal fluid examination and cranial ultrasound
were done in all patients. Blood culture, renal and liver function tests, computerised tomography scan,
metabolic and septic screening was done in selected patients. Descriptive statistics were applied for
analysis. Results: Tonic clonic seizure was the commonest type (28%) followed by multi-focal clonic,
and focal tonic seizures (25% each). Birth asphyxia was found to be the main aetiology (46%).
Conclusion: Tonic clonic seizure was the commonest type and birth asphyxia the main aetiology
identified in the majority of neonatal seizures.
Keywords: Neonatal seizures, Aetiology, Seizures, Epilepsy, Neonates

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Caravale B, Allemand F, Libenson MH. Factors predictive of

seizures and neurologic outcome in perinatal depression. Pediatr

Neurol 2003;29:18–25.

Holanda MRR, Melo AN. Comparative clinical study of preterm

and full-term newborn neonatal seizures. Arq Neuropsiquiatr


Patrizi S, Holmes GL, Orzalesi M, Allemand F. Neonatal

seizures: characteristics of EEG Ictal activity in preterm and

fullterm infants. Brain Dev 2003;25:427–37.

Gebremariam A, Gutema Y, Leuel A, Fekadu H. Early-onset

neonatal seizures: types, risk factors and short-term outcome.

Ann Trop Paediatr 2006;26:127–31.

Malik BA, Butt MA, Shamoon M, Tehseen Z, Fatima A,

Hashmat N. Seizures etiology in the newborn period. J Coll

Physicians Surg Pak 2005;15:786–90.

Sood A, Grover M, Sharma R. Biochemical abnormalities in

neonatal seizures. Indian J Pediatr 2003;70:221–4.

Upadhyay A, Aggarwal R, Deorari AK, Paul VK. Seizures in the

newborn. Indian J Pediatr 2001;68:967–72.

Laroia N. Neonatal seizures. Indian Pediatr 2000;37:367–72.

Zupanc ML. Neonatal seizures. Pediatr Clin North Am


Ballard JL, Khoury JC, Wedig K. New Ballard Score, expanded

to include extremely premature infants. J Pediatrics


Verrotti A, Latini G, Cicioni P, Felice CD. New trends in

neonatal seizures. J of Pediatr Neurol 2004;2:191–7.

Scher MS, Alvin J, Gaus L, Minnigh B, Painter MJ. Uncopoling

of EEG-clinical neonatal seizures after antiepileptic drug use.

Pediatr Neurol 2003;28:277–80.

Barkovich AJ. Brain and spine injuries in infancy and childhood:

diffuse ischemic brain injury. In: Pediatric Neuroimaging. 4th ed.

Philadelphia, PA: Lippincott Williams & Wilkins; 2005.p.203–44.

Rennie JM, Bylan GB. Neonatal seizures. In: David TJ, ed.

Recent Advances in Paediatrics 18. Edinburgh: Churchill

Livingstone; 2002.p. 19–32.

Park W, Kim DY, Jung CZ, Kim CD. Clinical study of neonatal

seizures. J Korean Child Neurol Soc 1998;6:71–82.

Alcover-Bloch E, Campistol J, Iriondo-Sanz M. Neonatal

seizures, our experience. Rev Neurol 2004;38:808–12.

Tekgul H, Gauvreau K, Soul J, Murphy L, Robertson R, Stewart

J. The Current Etiologic Profile and Neurodevelopmental

outcome of Seizures in Term Newborn Infants. Pediatrics


Ajay K, Ashish G, Bibek T. Clinico-etiological and EEG profile

of neonatal seizures. Indian J Pediatr 2007;74:33–7.

Tharp BR. Neonatal Seizures and syndromes. Epilepsia


Volpe JJ. Neonatal seizures. In: Neurology of the Newborn.

Philadelphia, PA: WB Saunders; 2001.p. 178–214.

Mizrahi EM, Kellaway P. Diagnosis and managment of neonatal

seizures. Philadelphia: Lippincot-Raven; 1998.p. 52–9.

Ronen GM, Penney S, Andrews W. The epidemiology of clinical

neonatal seizures in Newfoundland: a population-based study. J

Pediatr 1999;134:71–5.

SA, Hameed N, Maqbool S. Incidence and etiology of neonatal

seizures. Pak Paed J 2006;30:168–73.

Butt TK, Maqbool S, Ali L, Hamid H. Neonatal seizuresetiology, treatment and outcome. Pak Paed J 2005;29:151–6.

Mizrahi EM, Kellaway P. Characterization and Classification of

neonatal seizures. Neurology 1987;37:1837–44.

Ibrahim S, Parkash J. Birth asphyxia-analysis of 235 cases. J Pak

Med Assoc 2002;52:553–6.

Rufo-Campos M, Gonzalez Meneses-Lopez A, Rangel-Pineda C.

Cerebral seizures in neonatal period: semeiology, evolution and

factors of influence. Rev Neurol 2000;31:301–6.

Jin S, Hahn MD, Donald M, Olson MD. Etiology of neonatal

seizures. Neo Reviews 2004;5(8):e327–35.

Berger R, Garnier Y: Pathophysiology of perinatal brain damage.

Brain Res Brain Res Rev 1999;30:107–34.

Nordli DR Jr, De Vivo DC. Classification of infantile seizures,

implications for identification and treatment of inborn error of

metabolism. J Child Neurol 2002;17:353–8.

Naveen B, Vanitha AJ, Vijai Kumar HV, Gururaj S, Satish,

Rajashekhar. Etiological Profile of Neonatal Seizures in a

Referral Centre. Abstract of scientific paper presented at 20th

Annual convention of NNF at Mumbai, Nov. 2000.

Ijaz I, Khan HI. Risk factors of neonatal Tetanus. Pak Paediatr J


Pollina J, Dias MS, Li VK, Kachurek D, Arbesman M. Cranial

birth injuries in term newborn infants. Pediatr Neurosurg


Barkovich AJ, Kuzniecky RI, Jackson MD, Guerrini R, Dobyns

WB. Classification system for malformations of cortical

development. Neurology 2001;57:2168–78.

Laroia N. Current Controversies in Diagnosis and Management

of Neonatal Seizures. Indian Pediatr 2000;37:367–72.

Rennie JM, Boylan GB. Neonatal seizures and their treatment.

Curr Opin Neurol 2003;16:177–81.

Holanda MRR, Melo AN. Comparative clinical study of preterm

and full-term newborn neonatal seizures. Arq Neuropsiquiatr



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