FREQUENCY AND OUTCOME OF NECROTIZING ENTEROCOLITIS IN PRETERM NEONATES

Authors

  • Syed Sajid Hussain Shah
  • Munazza Saleem
  • Tahir Mehmood
  • Tausif Ahmed

Abstract

Background: Necrotizing enterocolitis (NEC) is the commonest gastrointestinal emergency in neonates. It is associated with high mortality and morbidity. Present study was conducted to determine the frequency of necrotizing enterocolitis in preterm neonates along with their outcome during stay in hospital. Methods: This was descriptive case series carried out in Neonatal Intensive Care Unit (NICU) of Paediatrics department, POF Hospital Wah Cantt from August 2010 to February 2011. All the preterm neonates admitted in NICU POF Hospital were included in the study. Patients were clerked on a pre-designed pro forma. Results: A total of 196 neonates were enrolled and 28 (14%) were diagnosed with NEC. Outcome analysis of these 28 patients with NEC revealed that 16 patients (57.14%) were discharged while 11 (39.28%) expired and one (3.5%) was referred. Conclusion: There is a high incidence in preterm-low birth weight babies presenting in our set-up, with high mortality rates.Keywords: Necrotizing enterocolitis, outcome, preterm, enteral feeding

References

Sweeney NMF. Neonatology Gastrointestinal diseases. In: Custer JW, Rau RE, editors. The Harriet Lane Handbook. Philadelphia: Mosby Elsevier; 2009. p. 499–500.

Bisquera JA, Cooper TR, Berseth CL. Impact of necrotizing enterocolitis on length of stay and hospital charges in very low birth weight infants. Pediatrics 2002;109:423–8.

Sisk PM, Lovelady CA, Dillard RG, Gruber KJ, O’Shea TM. Early human feeding is associated with a lower risk of necrotizing enterocolitis in very low birth weight infants. J Perinatol 2007;27:428–33.

Oliveira NDde, Miyoshi MH. Advances in necrotizing enterocolitis. J Pediatr 2005;81(1):16–22.

Berseth CL, Poenaru D. Necrotizing Entercolitis and Short Bowel Syndrome. In: Taeusch HW, Ballard RA, Gleason CA, editors. Avery’s Diseases of The Newborn. Philadelphia: Elsevier; 2005. p. 1123–33.

Luigi G, Roberto B, Vivana C, Mario DC. Necrotizing Entercolitis in Very low birth weight in Italy: Incidence and Non-nutritional risk factors. J Pediatric Gastroenterol Nutr 2008;47:206–10.

Bhandari V, Bizzaro MJ. Familial and Genetic susceptibility to Major Neonatal Morbidities in Preterm Twins. Pediatrics 2006;117:1901–6.

Shaul D, Ayala L, Brain R. Patent ductus arteriosis, Indomethacine and NEC in VLBW infants. A Population-Based Study. J Pediatric Gastroenterol Nutr 2005;40:184–8.

Guillet R, Stoll BJ, Cotten CM, Gantz M, McDonald S, Poole WK, Phelps DL. Association of H2-Blocker Therapy and Higher Incidence of Necrotizing Enterocolitis in Very Low Birth Weight Infants. Pediatrics 2006;117:137–42.

Oral Supplementation with lactobacillus casei Subspcies rhamnosus Prevents Enteric Colonization by Candida Species in Preterm Neonates. A Randomized Study. Clin Infect Dis 2006;42:1735–42.

Mancilla-Rairez J, Vera-Castro F, Martinez-hernandez FJ. Frequency of neonatal necrotizing enterocolitis at a pediatric hospital. Bol Med Hosp Infant Mex 1989;46(7):485-93.

Martin CR, Walker WA. Intestinal immune defences and the inflammatory response in necrotizing enterocolitis. Semin Fetal Neonatal Med 2006;11:369–77.

Lin PW, Stoll BJ. Necrotising enterocolitis. Lancet 2006;368:1271–83.

Horbar JD, Badger GJ, Carpenter JH, Fanaroff AA, Kilpatrick S, LaCorte M, et al. Trends in mortality and morbidity for very low birth weight infants, 1991-1999. Pediatrics 2002;110:143-51.

Henry MC, Lawrence Moss R. Surgical therapy for necrotizing enterocolitis: bringing evidence to bedside. SeminPediatr Surg 2005;14:181–90.

Srinivasan PS, Brandler MD, D'Souza A. Necrotizing enterocolitis. Clin Perinatol 2008;35:251-72.

Montgomery D, Schmutz N, Baer VL, Rogerson R, Wheeler R, Rowley AM, et al. Effects of instituting the "BEST Program" (Breast Milk Early Saves Trouble) in a level III NICU. J Hum Lact 2008;24(3):248-51.

Henderson G, Craig S, Brocklehurst P, McGuire W. Enteral feeding regimens and necrotising enterocolitis in preterm infants: a multicentre case-control study. Arch dis child fetal neonatal 2009;94(2):120–3.

Published

2015-03-01

Issue

Vol. 27 No. 1 (2015): JOURNAL OF AYUB MEDICAL COLLEGE, ABBOTTABAD

Section

ORIGINAL ARTICLE

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