MEASLES IN VACCINATED CHILDREN 1.5 TO 3 YEARS OF AGE IN RURAL COMMUNITY OF DISTRICT PESHAWAR, PAKISTAN
Abstract
Background: In many developing countries measles is a leading cause of childhood morbidity and mortality. Despite of vaccination thousands of children have been infected by measles virus during last couple of years in Pakistan. The objective of this study was to determine the measles vaccination coverage rate and frequency of measles among vaccinated children of age 1.5–3 years in rural community of district Peshawar. Methods: The cross-sectional study was carried out among 385 children aged 1.5–3 year of rural community of Peshawar. After taking informed consent from parents/guardians a predesigned questionnaire was filled. Evidence of vaccination and measles history was taken by vaccination card, doctor prescription and parent/guardian recall. Data was gathered and analysed by using SPSS-16. Results: Of the 385 children, 361 (93.7%) were vaccinated against measles at 9 month. It was found that 27 (7.48%) vaccinated children had measles history of which 23 (6.74%) were infected after 9 month vaccination. One hundred and ninety-two (49.8%) children were vaccinated both at 9 and 15 months, and 14 (7.29%) dual vaccinated children had a measles history, 9 among them (4.68%) were infected after taking both measles doses. Conclusion: The occurrence of measles among vaccinated children and low coverage rate of second dose of measles vaccine raises many questions about vaccination program and its efficacy. Further studies are needed to evaluate the influence of other predisposing factors like vaccine quality, manufacturer, supply, cold chain, handling, nutritional status of children and technical approach, on measles vaccine efficacy.References
Hashiguchi T, Maenaka K, Yanagi Y. Measles virus hemagglutinin: structural insights into cell entry and measles vaccine. Front Microbiol 2011;2:247.
Gindler J, Tinker S, Markowitz L, Atkinson W, Dales L, Papania MJ. Acute measles mortality in the United States, 1987–2002. J Infec Dis 2004;189(Suppl 1):69–77.
Muscat M, Bang H, Wohlfahrt J, Glismann S, Molbak K. Measles in Europe: an epidemiological assessment. Lancet 2009;373(9661):383–9.
Bugvi AS, Rahat R, Zakar R, Zakar MZ, Fischer F, Nasrullah M, et al. Factors associated with nonutilization of child immunization in Pakistan: evidence from the Demographic and Health Survey 2006-07. BMC Public Health 2014;14:232.
Sheikh S, Ali A, Zaidi AKM, Agha A, Khowaja A, Allana S, et al. Measles susceptibility in children in Karachi, Pakistan. Vaccine 2011;29(18):3419–23.
Khan A, Khan A. Childhood immunization in Pakistan. Res Dev Sol 2012;3:1–3.
Khan T, Qazi J. Measles outbreaks in Pakistan: causes of the tragedy and future implications. Epidemiol Rep 2014;2:1.
Cohen AL, Salam A, Bosan A, Perry R, Iqbal S, Qureshi SN, et al. Etiology of a suspected measles outbreak: preceding measles reduction activities in Pakistan. J Coll Physicians Surg Pak 2009;19(9):591–4.
Ariyasriwatana C, Kalatanarooj S. Severity of measles: a study at the Queen Sirikit National Institute of Child Health. J Med Assoc Thai 2004;87(6):581–8.
Tariq P. Assessment of coverage level of single dose measles vaccine. J Coll Physicians Surg Pak 2003;13(9):507–10.
Rahman A, Saeed A, Ali M. Assessment of Knowledge and practices of mothers regarding measles -2 Immunization for Children. Pak J Med Health Sci 2013;7(3):719.
Sheikh S, Ali A, Zaidi AK, Agha A, Khowaja A, Allana S, et al. Measles susceptibility in children in Karachi, Pakistan. Vaccine 2011;29(18):3419–23.
Zahoor MA, Rasool MH, Waseem M, Aslam1 A, Zahoor MK, Saqalein1 M, et al. Prevalence of measles in vaccinated and non-vaccinated children. (Letter to editor) J Excli 2015;14:504–7.
Rabenau HF, Marianov B, Allwinn R. Comparison of the neutralizing and ELISA antibody titres to measles virus in human sera and in gamma globulin preparations. Med Microbiol Immunol 2007;196(3):151–5.
Rahim F, Rehman HU, Afridi JM. Measles-demographic profile and complications in children. J Med Sci 2011;19:174–6.
Erickson L, De Wals P and Farand L. An analytical framework for immunization programs in Canada. Vaccine. 2005; 23: 2470-6.
Pickering LK, Wallace G. Rodewald L. Too hot, too cold: Issues with vaccine storage. Pediatrics 2006;118(4):1738–9.
Vaccine Handling and Storage - How to Provide Vaccinations to Adults - Complete Guide Book for Healthcare Professionals. p.21–34. [Internet].2004 [cited 2015 Jan 27]. Available from: http://www.immunize.org/guide/
Mohammad A, Irshad M, Khan B. A comparative study of measles complications in vaccinated versus non-vaccinated children. J Postgrad Med Inst 2011;25(1):4–8.
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